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An In Vivo Model System for Evaluation of the Host Response to Biomaterials

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Wound Regeneration and Repair

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1037))

Abstract

We describe an in vivo model system designed to evaluate the host response to implanted biomaterials: The partial thickness rat abdominal wall defect model. The model allows for determination of the temporal and spatial distribution of the cellular and vascular response, the remodeling of the implanted material and surrounding host soft tissue, and the function of the remodeled tissue over time.

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Author information

Authors and Affiliations

  1. Department of Cellular and Molecular Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Brian Sicari

  2. Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA

    Neill Turner & Stephen F. Badylak

  3. McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA

    Stephen F. Badylak

  4. Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA

    Stephen F. Badylak

Authors
  1. Brian Sicari
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  2. Neill Turner
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  3. Stephen F. Badylak
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Editor information

Editors and Affiliations

  1. Virginia Tech Carilion Research Institut, Roanoke, Virginia, USA

    Robert G. Gourdie

  2. School of Pharmacy, MCPHS University, Worcester, Massachusetts, USA

    Tereance A. Myers

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Sicari, B., Turner, N., Badylak, S.F. (2013). An In Vivo Model System for Evaluation of the Host Response to Biomaterials. In: Gourdie, R., Myers, T. (eds) Wound Regeneration and Repair. Methods in Molecular Biology, vol 1037. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-505-7_1

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  • DOI: https://doi.org/10.1007/978-1-62703-505-7_1

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-504-0

  • Online ISBN: 978-1-62703-505-7

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