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TRPs to Cardiovascular Disease

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TRP Channels in Drug Discovery

Part of the book series: Methods in Pharmacology and Toxicology ((MIPT))

Abstract

Transient receptor potential (TRP) is a large superfamily of cation channels comprising 28 members in mammals. TRP channels are ubiquitously expressed in human tissues, including the cardiovascular system where they have been associated with a number of physiological functions, such as proliferation, contraction, and migration. TRP channels comprise six large families of cation channels: TRPC, TRPM, TRPV, TRPP, TRPA, and TRPML with diverse ion selectivities and modes of activation. Depending on the isoform considered, activation of TRP channels can cause entry of Ca2+, Na+, or Mg2+ into cells. TRP channels have recently emerged as attractive drug targets for treatment of cardiovascular diseases since their expression and/or activation was shown to be disturbed in certain pathophysiological conditions, such as cardiac hypertrophy and hypertension. In this short review, we will summarize data on the expression of TRP channels in the three major cell types of the cardiovascular system: cardiomyocytes, endothelial cells, and smooth muscle cells and will review evidence for the involvement of TRP channels in mediating cardiovascular disease.

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Authors and Affiliations

  1. The Center for Cardiovascular Sciences, Albany Medical College, Albany, NY, USA

    José C. González-Cobos, Xuexin Zhang, Rajender K. Motiani, Kelly E. Harmon & Mohamed Trebak

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  1. José C. González-Cobos
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  2. Xuexin Zhang
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  3. Rajender K. Motiani
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  4. Kelly E. Harmon
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  5. Mohamed Trebak
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Correspondence to Mohamed Trebak .

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Editors and Affiliations

  1. Transfusion Services, Monmouth Medical Center, Long Branch, New Jersey, USA

    Arpad Szallasi

  2. Department of Physiology, University of Debrecen Medical and Health Science Center, Debrecen, Hungary

    Tamás Bíró

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González-Cobos, J.C., Zhang, X., Motiani, R.K., Harmon, K.E., Trebak, M. (2012). TRPs to Cardiovascular Disease. In: Szallasi, A., Bíró, T. (eds) TRP Channels in Drug Discovery. Methods in Pharmacology and Toxicology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-095-3_1

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