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Development and Use of TCR Transgenic Mice for Malaria Immunology Research

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Malaria

Part of the book series: Methods in Molecular Biology ((MIMB,volume 923))

Abstract

T-cell receptor transgenic mice are powerful tools to study T cell responses to malaria parasites. They allow for a population of antigen specific T cells to be monitored during developing responses to immunization or parasite infection; this makes them particularly useful to study fundamental aspects of T cell activation, differentiation, and migration in different tissue compartments. Moreover, the use of these cells allows for a thorough analysis of the mechanisms of antiparasite activity by T cells.

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Acknowledgments

We thank Ian Cockburn and Eric Wan for reviewing and editing the manuscript. The research of FZ is supported by NIH grant number AI44375. We thank the Bloomberg Family Foundation for its kind support.

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Authors and Affiliations

  1. Department of Molecular Microbiology and Immunology, John Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

    Yun-Chi Chen & Fidel Zavala

Authors
  1. Yun-Chi Chen
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  2. Fidel Zavala
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Corresponding author

Correspondence to Fidel Zavala .

Editor information

Editors and Affiliations

  1. , Malaria Biology and Genetics Unit, Institut Pasteur, Rue du Dr Roux 28, Paris, 75724, France

    Robert Ménard

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Chen, YC., Zavala, F. (2012). Development and Use of TCR Transgenic Mice for Malaria Immunology Research. In: Ménard, R. (eds) Malaria. Methods in Molecular Biology, vol 923. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-026-7_33

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  • DOI: https://doi.org/10.1007/978-1-62703-026-7_33

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-025-0

  • Online ISBN: 978-1-62703-026-7

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