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Gene Therapy of Salivary Diseases

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Oral Biology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 666))

Abstract

For many years, our laboratory has been developing gene transfer approaches for salivary gland disorders that currently lack effective therapy. The purpose of this chapter is to describe key methods used in this developmental process. Specifically, we focus on one clinical condition, irradiation-induced salivary hypofunction, and address the choice of transgene and vector to be used, the construction of recombinant viral vectors, how vector delivery is accomplished, and methods for assessing vector function in vitro and in an appropriate animal model.

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Acknowledgment

The authors’ research is supported by the intramural research program of the National Institute of Dental and Craniofacial Research.

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Authors and Affiliations

  1. Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA

    Bruce J. Baum, Janik Adriaansen, Ana P. Cotrim, Corinne M. Goldsmith, Paola Perez, Senrong Qi, Anne M. Rowzee & Changyu Zheng

Authors
  1. Bruce J. Baum
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  2. Janik Adriaansen
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  3. Ana P. Cotrim
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  4. Corinne M. Goldsmith
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  5. Paola Perez
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  6. Senrong Qi
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  7. Anne M. Rowzee
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  8. Changyu Zheng
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Editor information

Editors and Affiliations

  1. Faculty of Dentistry, Department of Oral Sciences, University of Otago, Great King Street 310, Dunedin, 9016, New Zealand

    Gregory J. Seymour

  2. Faculty of Dentistry, Department of Oral Sciences, University of Otago, Great King Street 310, Dunedin, 9016, New Zealand

    Mary P. Cullinan

  3. Faculty of Dentistry, Sir John Walsh Research Institute, University of Otago, Great King Street 310, Dunedin, 9016, New Zealand

    Nicholas C.K. Heng

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Baum, B.J. et al. (2010). Gene Therapy of Salivary Diseases. In: Seymour, G., Cullinan, M., Heng, N. (eds) Oral Biology. Methods in Molecular Biology, vol 666. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-820-1_1

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  • DOI: https://doi.org/10.1007/978-1-60761-820-1_1

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60761-819-5

  • Online ISBN: 978-1-60761-820-1

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