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Model of Acute Injury to Study Neuroprotection

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Neuroprotection Methods and Protocols

Part of the book series: Methods in Molecular Biology ((MIMB,volume 399))

Abstract

A major causative factor in the paralysis that often follows an acute injury to the central nervous system (CNS) is the paradoxical inability of the CNS to tolerate its own mechanism of self-repair. The dismal result is often a wider spread of damage (part of the inevitable “secondary” or “delayed” degeneration) rather than contribution toward a cure. Ever since the phenomenon of posttraumatic damage spread in the CNS was first recognized, neuroscientists have attempted to identify the players in this destructive process and have sought ways to neutralize or bypass them with the object of rescuing any neurons that are still viable. This approach is collectively termed neuroprotection. In this chapter, we present a view of experimental paradigms used to study neuroprotection.

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Author information

Authors and Affiliations

  1. Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel

    Michal Schwartz & Jonathan Kipnis

  2. Department of Pharmacology and Experimental Neuroscience and Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE

    Jonathan Kipnis

Authors
  1. Michal Schwartz
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  2. Jonathan Kipnis
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Tiziana Borsello

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© 2007 Humana Press Inc.

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Schwartz, M., Kipnis, J. (2007). Model of Acute Injury to Study Neuroprotection. In: Borsello, T. (eds) Neuroprotection Methods and Protocols. Methods in Molecular Biology, vol 399. Humana Press. https://doi.org/10.1007/978-1-59745-504-6_4

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  • DOI: https://doi.org/10.1007/978-1-59745-504-6_4

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-666-5

  • Online ISBN: 978-1-59745-504-6

  • eBook Packages: Springer Protocols

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