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A Novel Preclinical Rat Model of Alzheimer’s Disease

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Basic Neurobiology Techniques

Part of the book series: Neuromethods ((NM,volume 152))

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Abstract

We have developed a novel rat model that correlates with seemingly normal individuals who are predisposed (at-risk) to developing Alzheimer’s disease (AD). This work summarizes the findings we have reported on the effect of chronic psychosocial stress in this at-risk rat model of AD. Behavioral (learning and memory tests), electrophysiological (evoked LTP) and molecular (determining protein levels of signaling molecules) studies suggest that even mild chronic psychosocial stress can converts this seemingly normal rat into one showing clear AD phenotype. It is well known that vast individual variations exist in the time of onset and severity of the sporadic type of AD. Therefore, a patient-related external factor must be assumed to play a significant role in the development of the sporadic type of the disease. Since stress is increasingly recognized as an external factor in the development of AD, we tested the effect of mild psychosocial stress on our at-risk model.

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  1. Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA

    Karim A. Alkadhi

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  1. Karim A. Alkadhi
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  1. Levine College of Health Sciences, Wingate University, Wingate, NC, USA

    Nicholas J. D. Wright

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Alkadhi, K.A. (2020). A Novel Preclinical Rat Model of Alzheimer’s Disease. In: Wright, N. (eds) Basic Neurobiology Techniques . Neuromethods, vol 152. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9944-6_4

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  • DOI: https://doi.org/10.1007/978-1-4939-9944-6_4

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