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Stress and Systemic Inflammation: Yin-Yang Dynamics in Health and Diseases

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Psychoneuroimmunology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1781))

Abstract

Studies in psychoneuroimmunology (PNI) would provide better insights into the “whole mind-body system.” Systems biology models of the complex adaptive systems (CASs), such as a conceptual framework of “Yin-Yang dynamics,” may be helpful for identifying systems-based biomarkers and targets for more effective prevention and treatment. The disturbances in the Yin-Yang dynamical balance may result in stress, inflammation, and various disorders including insomnia, Alzheimer’s disease, obesity, diabetes, cardiovascular diseases, skin disorders, and cancer. At the molecular and cellular levels, the imbalances in the cytokine pathways, mitochondria networks, redox systems, and various signaling pathways may contribute to systemic inflammation. In the nervous system, Yin and Yang may represent the dynamical associations between the progressive and regressive processes in aging and neurodegenerative diseases. In response to the damages to the heart, the Yin-Yang dynamical balance between proinflammatory and anti-inflammatory cytokine networks is crucial. The studies of cancer have revealed the importance of the Yin-Yang dynamics in the tumoricidal and tumorigenic activities of the immune system. Stress-induced neuroimmune imbalances are also essential in chronic skin disorders including atopic dermatitis and psoriasis. With the integrative framework, the restoration of the Yin-Yang dynamics can become the objective of dynamical systems medicine.

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Author information

Authors and Affiliations

  1. PharmTao, Santa Clara, CA, USA

    Qing Yan

  2. University of Maryland University College, Adelphi, MD, USA

    Qing Yan

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  1. Qing Yan
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Correspondence to Qing Yan .

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Editors and Affiliations

  1. University of Maryland University College, Adelphi, MD, PharmTao, Santa Clara, California, USA

    Qing Yan

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Yan, Q. (2018). Stress and Systemic Inflammation: Yin-Yang Dynamics in Health and Diseases. In: Yan, Q. (eds) Psychoneuroimmunology. Methods in Molecular Biology, vol 1781. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7828-1_1

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  • DOI: https://doi.org/10.1007/978-1-4939-7828-1_1

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7827-4

  • Online ISBN: 978-1-4939-7828-1

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