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Investigation of Paternal Programming of Breast Cancer Risk in Female Offspring in Rodent Models

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Investigations of Early Nutrition Effects on Long-Term Health

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1735))

Abstract

Emerging experimental evidence show that fathers’ experiences during preconception can influence their daughters’ risk of developing breast cancer. Here we describe detailed protocols for investigation in rats and mice of paternally mediated breast cancer risk programming effects.

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Acknowledgments

C.C.F. was a recipient of a Ph.D. scholarship from the Brazilian National Council for Scientific and Technological Development (CNPq; Proc. 153478/2012-8). T.P.O. is the recipient of a researcher fellowship from CNPq (Proc. 307910/2016-4) and is supported by grants from CNPq (Proc. 448501/2014-7), the Food Research Center (FoRC), and the São Paulo State Research Funding Agency (Proc. 2013/07914-8). S.D.A. is supported by grants from the National Institutes of Health (K22CA178309-01A1) and the American Cancer Society (Research Scholar Grant).

Author information

Authors and Affiliations

  1. Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo and Food Research Center (FoRC), São Paulo, Brazil

    Camile Castilho Fontelles & Thomas Prates Ong

  2. Georgetown University Lombardi Comprehensive Cancer Center, Washington, DC, USA

    Camile Castilho Fontelles, Raquel Santana da Cruz, Leena Hilakivi-Clarke & Sonia de Assis

Authors
  1. Camile Castilho Fontelles
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  2. Raquel Santana da Cruz
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  3. Leena Hilakivi-Clarke
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  4. Sonia de Assis
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  5. Thomas Prates Ong
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Corresponding author

Correspondence to Thomas Prates Ong .

Editor information

Editors and Affiliations

  1. Debden, Essex, United Kingdom

    Paul C. Guest

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Fontelles, C.C., da Cruz, R.S., Hilakivi-Clarke, L., de Assis, S., Ong, T.P. (2018). Investigation of Paternal Programming of Breast Cancer Risk in Female Offspring in Rodent Models. In: Guest, P. (eds) Investigations of Early Nutrition Effects on Long-Term Health. Methods in Molecular Biology, vol 1735. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7614-0_11

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  • DOI: https://doi.org/10.1007/978-1-4939-7614-0_11

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7613-3

  • Online ISBN: 978-1-4939-7614-0

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