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Platforms for Recombinant Therapeutic Glycoprotein Production

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Recombinant Glycoprotein Production

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1674))

Abstract

The majority of FDA-approved biology-derived products are recombinant glycoproteins. These proteins have been used for the treatment of several diseases, with numerous products currently approved for clinical use. The choice of the expression system is a key step toward a successful functional protein production, since glycosylation influences yield, pharmacokinetics, biological activity, and immunogenicity. This chapter covers the general aspects of therapeutic recombinant glycoproteins and the platforms that are being employed for their production.

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Acknowledgment

The authors acknowledge the São Paulo Research Foundation – FAPESP (Grants 2012/04629-8, 2013/08135-2 and 2016/02433-0), CAPES scholarship and the Center for Cell-based Therapy/CTC/FAPESP (Regional Blood Center of Ribeirão Preto) for financial support.

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Authors and Affiliations

  1. Center for Cell-based Therapy CTC, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil

    Amanda Mizukami, Angelo Luis Caron, Virgínia Picanço-Castro & Kamilla Swiech

  2. School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil

    Angelo Luis Caron & Kamilla Swiech

Authors
  1. Amanda Mizukami
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  2. Angelo Luis Caron
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  3. Virgínia Picanço-Castro
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  4. Kamilla Swiech
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Corresponding author

Correspondence to Kamilla Swiech .

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Editors and Affiliations

  1. Regional Blood Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil

    Virgínia Picanço-Castro

  2. School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil

    Kamilla Swiech

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Mizukami, A., Caron, A.L., Picanço-Castro, V., Swiech, K. (2018). Platforms for Recombinant Therapeutic Glycoprotein Production. In: Picanço-Castro, V., Swiech, K. (eds) Recombinant Glycoprotein Production. Methods in Molecular Biology, vol 1674. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7312-5_1

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  • DOI: https://doi.org/10.1007/978-1-4939-7312-5_1

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7311-8

  • Online ISBN: 978-1-4939-7312-5

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