Abstract
Genetic analysis of Egfr signaling in Drosophila has a long-standing track record of making important contributions to our understanding of the Egfr pathway. While the central Ras/MAPK pathway has long been well defined, there is much to learn with regard to its cross talk with other pathways and how it is regulated. A better understanding of the regulation of Egfr signaling is of particular interest with regard to the participation of misregulated Egfr signaling in tumorigenesis. Recent studies in the fly have led to some surprising results, identifying regulators of Egfr acting in unexpected ways.
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References
Shilo BZ (2003) Signaling by the drosophila epidermal growth factor receptor pathway during development. Exp Cell Res 284(1):140–149. doi:S0014482702000940 [pii]
Shilo BZ (2005) Regulating the dynamics of EGF receptor signaling in space and time. Development 132(18):4017–4027. doi:10.1242/dev.02006
Martin-Bermudo MD, Bardet PL, Bellaiche Y, Malartre M (2015) The vav oncogene antagonises EGFR signalling and regulates adherens junction dynamics during drosophila eye development. Development 142(8):1492–1501. doi:10.1242/dev.110585
Macagno JP, Diaz Vera J, Yu Y, MacPherson I, Sandilands E, Palmer R, Norman JC, Frame M, Vidal M (2014) FAK acts as a suppressor of RTK-MAP kinase signalling in Drosophila melanogaster epithelia and human cancer cells. PLoS Genet 10(3):e1004262. doi:10.1371/journal.pgen.1004262
Molnar C, de Celis JF (2013) Tay bridge is a negative regulator of EGFR signalling and interacts with Erk and Mkp3 in the Drosophila melanogaster wing. PLoS Genet 9(12):e1003982. doi:10.1371/journal.pgen.1003982
Legent K, Liu HH, Treisman JE (2015) Drosophila Vps4 promotes epidermal growth factor receptor signaling independently of its role in receptor degradation. Development 142(8):1480–1491. doi:10.1242/dev.117960
Sulzmaier FJ, Jean C, Schlaepfer DD (2014) FAK in cancer: mechanistic findings and clinical applications. Nat Rev Cancer 14(9):598–610. doi:10.1038/nrc3792
Lazer G, Katzav S (2011) Guanine nucleotide exchange factors for RhoGTPases: good therapeutic targets for cancer therapy? Cell Signal 23(6):969–979. doi:10.1016/j.cellsig.2010.10.022
Tomas A, Futter CE, Eden ER (2014) EGF receptor trafficking: consequences for signaling and cancer. Trends Cell Biol 24(1):26–34. doi:10.1016/j.tcb.2013.11.002
Miura GI, Roignant JY, Wassef M, Treisman JE (2008) Myopic acts in the endocytic pathway to enhance signaling by the drosophila EGF receptor. Development 135(11):1913–1922. doi:10.1242/dev.017202
Vaccari T, Rusten TE, Menut L, Nezis IP, Brech A, Stenmark H, Bilder D (2009) Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in drosophila by efficient isolation of ESCRT mutants. J Cell Sci 122(Pt 14):2413–2423. doi:10.1242/jcs.046391
Henriksen L, Grandal MV, Knudsen SL, van Deurs B, Grovdal LM (2013) Internalization mechanisms of the epidermal growth factor receptor after activation with different ligands. PLoS One 8(3):e58148. doi:10.1371/journal.pone.0058148
Sousa LP, Lax I, Shen H, Ferguson SM, De Camilli P, Schlessinger J (2012) Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane. Proc Natl Acad Sci U S A 109(12):4419–4424. doi:10.1073/pnas.1200164109
Stepanenko AA, Vassetzky YS, Kavsan VM (2013) Antagonistic functional duality of cancer genes. Gene 529(2):199–207. doi:10.1016/j.gene.2013.07.047
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Harden, N. (2017). New Insights from Drosophila into the Regulation of EGFR Signaling. In: Wang, Z. (eds) ErbB Receptor Signaling. Methods in Molecular Biology, vol 1652. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7219-7_2
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DOI: https://doi.org/10.1007/978-1-4939-7219-7_2
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