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How to Avoid Bumping into the Translational Roadblock

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Rodent Models of Stroke

Part of the book series: Neuromethods ((NM,volume 120))

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Abstract

Translating neuroprotective efficacy from animal studies to clinical trials in humans has been fraught with difficulty. This failure might be because animal studies were falsely positive or because clinical trials were falsely negative. Alternatively, animal studies as currently conducted may not model human stroke with sufficient fidelity to be a useful predictor of efficacy in clinical trials.

Here we focus on measures to improve the design, conduct, and reporting of animal studies to maximize both their internal and their external validity. These include, but are not limited to, randomization, allocation concealment, blinded assessment of outcome, sample size calculation, and measures to avoid publication bias. In addition, we give a brief introduction to systematic review and meta-analysis of data from animal experiments.

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References

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Author information

Authors and Affiliations

  1. Centre for Clinical Neurosciences, University of Edinburgh, Crewe Road South, EH4 2XU, Edinburgh, Scotland, UK

    Malcolm R. Macleod Ph.D., F.R.C.P.E. & Emily Sena B.Sc. (Hons), Ph.D.

  2. Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies, Edinburgh, UK

    Malcolm R. Macleod Ph.D., F.R.C.P.E. & Emily Sena B.Sc. (Hons), Ph.D.

Authors
  1. Malcolm R. Macleod Ph.D., F.R.C.P.E.
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  2. Emily Sena B.Sc. (Hons), Ph.D.
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Corresponding author

Correspondence to Malcolm R. Macleod Ph.D., F.R.C.P.E. .

Editor information

Editors and Affiliations

  1. Department of Experimental Neurology and Center for Stroke Research Berlin (CSB), Charité-Universitätsmedizin Berlin, Berlin, Germany

    Ulrich Dirnagl

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Macleod, M.R., Sena, E. (2016). How to Avoid Bumping into the Translational Roadblock. In: Dirnagl, U. (eds) Rodent Models of Stroke. Neuromethods, vol 120. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-5620-3_2

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  • DOI: https://doi.org/10.1007/978-1-4939-5620-3_2

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-5618-0

  • Online ISBN: 978-1-4939-5620-3

  • eBook Packages: Springer Protocols

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