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Behavioral Testing in Rodent Models of Stroke, Part I

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Rodent Models of Stroke

Part of the book series: Neuromethods ((NM,volume 120))

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Abstract

For the past decades, experimental intervention showed therapeutic promise in animal models of stroke has largely failed to produce beneficial effects in human stroke patients. The difficulty in translating preclinical findings represents a major challenge in cerebrovascular research. The reasons for this translational road block might be explained by a number of factors, including poor quality control in various stages of the research process, insufficient experimental power, the validity of experimental stroke model, and the different choices of end point or outcome measures. In this chapter, we present, next to general introduction to behavioral research in rodents, some widely used and reliable behavioral tests by which various sensory, motoric, cognitive, and psychological impairments in rodent stroke models can be assessed. Each test is described in detail and important protocol keypoints for successful testing in rodent stroke models are included.

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Authors and Affiliations

  1. Department of Experimental Neurology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany

    René Bernard

  2. Department of Physiology, Bahçeşehir University Istanbul, Istanbul, Turkey

    Mustafa Balkaya

  3. Department of Experimental Neurology and Center for Stroke Research Berlin (CSB), Charité-Universitätsmedizin Berlin, Charitéplatz 110117, Berlin, Germany

    André Rex

Authors
  1. René Bernard
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  2. Mustafa Balkaya
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  3. André Rex
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Correspondence to René Bernard .

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Editors and Affiliations

  1. Department of Experimental Neurology and Center for Stroke Research Berlin (CSB), Charité-Universitätsmedizin Berlin, Berlin, Germany

    Ulrich Dirnagl

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Bernard, R., Balkaya, M., Rex, A. (2016). Behavioral Testing in Rodent Models of Stroke, Part I. In: Dirnagl, U. (eds) Rodent Models of Stroke. Neuromethods, vol 120. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-5620-3_13

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  • DOI: https://doi.org/10.1007/978-1-4939-5620-3_13

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-5618-0

  • Online ISBN: 978-1-4939-5620-3

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