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Cell-Type Specific GRK2 Interactomes: Pathophysiological Implications

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G Protein-Coupled Receptor Kinases

Part of the book series: Methods in Pharmacology and Toxicology ((MIPT))

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Abstract

G protein-coupled receptor kinase 2 (GRK2) is emerging as a key hub in cell signaling cascades. In addition to modulating activated G protein-coupled receptors, GRK2 can phosphorylate and/or functionally interact with a complex network of cellular proteins in a cell-type and physiological context-dependent way. A combination of such canonical and noncanonical interactions underlies the participation of this kinase in the control of cell migration, proliferation or metabolism and in integrated processes at the tissue or whole organism levels, such as angiogenesis, cardiovascular function, or insulin resistance, among others. Its role as a signaling node and the fact that altered levels of GRK2 are detected in a variety of pathological conditions put forward this protein as a potentially relevant diagnostic and therapeutic target.

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Acknowledgments

Our laboratory is supported by Grants SAF2014-55511-R (to F.M. and C.M.) from Ministerio de Economía y Competitividad (MINECO), Spain; PI14/00435 from Instituto de Salud Carlos III to P.P., S2010/BMD-2332 (INDISNET) from Comunidad de Madrid, Spain (to F.M.); The Cardiovascular Network (RD12/0042/0012), from Ministerio Sanidad y Consumo-Instituto Carlos III, Spain (to F.M.), an European Foundation for the Study of Diabetes (EFSD) Novo Nordisk Partnership for Diabetes Research in Europe Grant (to F.M.); Fundación Ramón Areces (to C.M. and P.P.). We also acknowledge the support of a Contrato para la Formación Postdoctoral from MINECO to R.V.B., and institutional support from Fundación Ramón Areces.

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Authors and Affiliations

  1. Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Universidad Autónoma de Madrid, C/Nicolás Cabrera 1, 28049, Madrid, Spain

    Federico Mayor Jr., Rocío Vila-Bedmar, Laura Nogués, Marta Cruces-Sande, Elisa Lucas, Verónica Rivas, Clara Reglero, Petronila Penela & Cristina Murga

  2. Instituto de Investigación Sanitaria La Princesa, 28006, Madrid, Spain

    Federico Mayor Jr., Rocío Vila-Bedmar, Laura Nogués, Marta Cruces-Sande, Elisa Lucas, Verónica Rivas, Clara Reglero, Petronila Penela & Cristina Murga

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  1. Federico Mayor Jr.
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  2. Rocío Vila-Bedmar
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  9. Cristina Murga
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Correspondence to Federico Mayor Jr. .

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Editors and Affiliations

  1. Department of Pharmacology, Vanderbilt University , NASHVILLE, Tennessee, USA

    Vsevolod V. Gurevich

  2. Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, USA

    Eugenia V. Gurevich

  3. Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA

    John J.G. Tesmer

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Mayor, F. et al. (2016). Cell-Type Specific GRK2 Interactomes: Pathophysiological Implications. In: Gurevich, V., Gurevich, E., Tesmer, J. (eds) G Protein-Coupled Receptor Kinases. Methods in Pharmacology and Toxicology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3798-1_6

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  • DOI: https://doi.org/10.1007/978-1-4939-3798-1_6

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