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G Protein-Coupled Receptor Kinases

  • Vsevolod V. Gurevich
  • Eugenia V. Gurevich
  • John J.G. Tesmer

Part of the Methods in Pharmacology and Toxicology book series (MIPT)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Vsevolod V. Gurevich, Eugenia V. Gurevich
      Pages 3-22
  3. GRK Structure, Mechanisms of Activation, and Interactions with GPCRs

    1. Front Matter
      Pages 23-23
    2. Tivadar Orban, Krzysztof Palczewski
      Pages 25-43
    3. Chih-Chun Hsu, Ching-Kang Jason Chen
      Pages 45-57
  4. GRKs in Cell Signaling

    1. Front Matter
      Pages 121-121
    2. Federico Mayor Jr., Rocío Vila-Bedmar, Laura Nogués, Marta Cruces-Sande, Elisa Lucas, Verónica Rivas et al.
      Pages 123-149
    3. Leonard Girnita, Ada Girnita, Caitrin Crudden
      Pages 151-171
    4. Adi Raveh, Liora Guy-David, Eitan Reuveny
      Pages 173-183
  5. Physiological and Pathophysiological Mechanisms Regulated by GRKs

    1. Front Matter
      Pages 185-185
    2. Faiza Baameur, Pooja Singhmar, Cobi J. Heijnen, Annemieke Kavelaars
      Pages 187-213
    3. Eugenia V. Gurevich, Raul R. Gainetdinov, Vsevolod V. Gurevich
      Pages 237-269
    4. Alessandro Cannavo, Claudio de Lucia, Walter J. Koch
      Pages 271-281
    5. Jordan F. Wood, Denise M. Ferkey
      Pages 283-299
  6. Back Matter
    Pages 325-329

About this book

Introduction

This collection explores up-to-date descriptions of known G protein-coupled receptor kinase (GRK)-dependent mechanisms, both associated with G protein-coupled receptor (GPCR) functions and the receptor-independent. The chapters cover a wide range of studies from invertebrates to humans, with sections of the volume covering GRK structure, mechanisms of activation, and interaction with GPCRs, GRKs in cell signaling, as well as physiological and pathophysiological mechanisms regulated by GRKs.  Written for the Methods in Pharmacology and Toxicology series, this book features the kind of practical detail necessary for success in the laboratory. 
Authoritative and timely, G Protein-Coupled Receptor Kinases features the kind of comprehensive mechanistic elucidation of GRK functions and their regulation in cells necessary for a better understanding of cell biology as well as for devising novel research approaches and therapeutic strategies.

Keywords

G protein-coupled receptors (GPCRs) Cell signaling Pathophysiological regulation GPCR signaling GRK phosphorylation Therapeutic strategies GRKs

Editors and affiliations

  • Vsevolod V. Gurevich
    • 1
  • Eugenia V. Gurevich
    • 2
  • John J.G. Tesmer
    • 3
  1. 1.Department of PharmacologyVanderbilt University NASHVILLEUSA
  2. 2.Department of PharmacologyVanderbilt UniversityNashvilleUSA
  3. 3.Life Sciences InstituteUniversity of MichiganAnn ArborUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4939-3798-1
  • Copyright Information Springer Science+Business Media New York 2016
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-3796-7
  • Online ISBN 978-1-4939-3798-1
  • Series Print ISSN 1557-2153
  • Series Online ISSN 1940-6053
  • Buy this book on publisher's site
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