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Novel Adjuvants and Immunomodulators for Veterinary Vaccines

  • Protocol
Vaccine Technologies for Veterinary Viral Diseases

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1349))

Abstract

Adjuvants are crucial for efficacy of vaccines, especially subunit and recombinant vaccines. Rational vaccine design, including knowledge-based and molecularly defined adjuvants tailored for directing and potentiating specific types of host immune responses towards the antigens included in the vaccine is becoming a reality with our increased understanding of innate and adaptive immune activation. This will allow future vaccines to induce immune reactivity having adequate specificity as well as protective and recallable immune effector mechanisms in appropriate body compartments, including mucosal surfaces. Here we describe these new developments and, when possible, relate new immunological knowledge to the many years of experience with traditional, empirical adjuvants. Finally, some protocols are given for production of emulsion (oil-based) and liposome-based adjuvant/antigen formulations.

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Acknowledgement

This work was supported by the EU Network of Excellence, EPIZONE (Contract No FOOD-CT-2006-016236). Dr. Nanna Skall Sørensen (DTU Vet) is thanked for allowing access to unpublished data (Figure 2b).

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Authors and Affiliations

  1. Section for Immunology and Vaccinology, National Veterinary Institute, Technical University of Denmark, Bülowsvej 27, 1870, Frederiksberg C, Denmark

    Peter M. H. Heegaard, Yongxiang Fang & Gregers Jungersen

  2. State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Public Health of Ministry of Agriculture, Lanzhou Veterinary Research Institute, CAAS, Lanzhou, 730046, China

    Yongxiang Fang

Authors
  1. Peter M. H. Heegaard
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  2. Yongxiang Fang
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  3. Gregers Jungersen
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Corresponding author

Correspondence to Peter M. H. Heegaard .

Editor information

Editors and Affiliations

  1. CISA-INIA, Valdeolmos, Madrid, Spain

    Alejandro Brun

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Heegaard, P.M.H., Fang, Y., Jungersen, G. (2016). Novel Adjuvants and Immunomodulators for Veterinary Vaccines. In: Brun, A. (eds) Vaccine Technologies for Veterinary Viral Diseases. Methods in Molecular Biology, vol 1349. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3008-1_5

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  • DOI: https://doi.org/10.1007/978-1-4939-3008-1_5

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-3007-4

  • Online ISBN: 978-1-4939-3008-1

  • eBook Packages: Springer Protocols

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