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A Procedure for Developing Quantitative Near Infrared (NIR) Methods for Pharmaceutical Products

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Process Simulation and Data Modeling in Solid Oral Drug Development and Manufacture

Part of the book series: Methods in Pharmacology and Toxicology ((MIPT))

Abstract

The pharmaceutical industry uses procedures to describe all the instructions needed to perform a process in a consistent manner. Procedures are based on process knowledge and the desire to consistently meet desired specifications. This chapter proposes a procedure for the development of NIR partial least squares (PLS) calibration models for pharmaceutical applications. The chapter captures the lessons learned for more than a decade in studies where NIR spectroscopy has been used for quantitative determinations of drug concentration, moisture, polymorphs, and other important applications. Two examples of recent initiatives to develop NIR calibration models in a more efficient manner reducing the number of calibration samples are also discussed. The procedure differs from previously published guidelines since it is based on specific examples of method validations for pharmaceutical processes and provides clear instructions for method development and validation. The procedure and tutorial should advance the implementation of near infrared spectroscopic (NIRS) quantitative methods in the pharmaceutical industry.

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Acknowledgements

This work was performed thanks to the support of the NSF ERC Structured Organic Particulate Systems EEC-0540855 grant. The authors thank two industrial advisors in this grant: Dongsheng Bu from BMS and Pius Tse from Merck for carefully reviewing the manuscript. Graduate student Krizia Karry and Yusuf Suluf (SABIC Innovative Plastics) are also thanked for their reviews.

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Authors and Affiliations

  1. Department of Chemistry, Recinto Universitario de Mayagüez, 9000, Mayagüez, PR, 00681, USA

    Rodolfo J. Romañach & Andrés D. Román-Ospino

  2. Grup de Quimiometría Aplicada, Departament de Química, Unitat de Química Analítica, Universitat Autònoma de Barcelona, Edifici Cn, Campus de la UAB, 08193, Bellaterra, Barcelona, Spain

    Manel Alcalà

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  1. Rodolfo J. Romañach
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  2. Andrés D. Román-Ospino
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  3. Manel Alcalà
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Correspondence to Rodolfo J. Romañach .

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Editors and Affiliations

  1. Rutgers University, Piscataway, NJ, USA

    Marianthi G. Ierapetritou  & Rohit Ramachandran  & 

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Romañach, R.J., Román-Ospino, A.D., Alcalà, M. (2016). A Procedure for Developing Quantitative Near Infrared (NIR) Methods for Pharmaceutical Products. In: Ierapetritou, M.G., Ramachandran, R. (eds) Process Simulation and Data Modeling in Solid Oral Drug Development and Manufacture. Methods in Pharmacology and Toxicology. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-2996-2_5

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  • DOI: https://doi.org/10.1007/978-1-4939-2996-2_5

  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-4939-2995-5

  • Online ISBN: 978-1-4939-2996-2

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