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Integrating Proteomics Profiling Data Sets: A Network Perspective

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Clinical Proteomics

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1243))

Abstract

Understanding disease mechanisms often requires complex and accurate integration of cellular pathways and molecular networks. Systems biology offers the possibility to provide a comprehensive map of the cell’s intricate wiring network, which can ultimately lead to decipher the disease phenotype. Here, we describe what biological pathways are, how they function in normal and abnormal cellular systems, limitations faced by databases for integrating data, and highlight how network models are emerging as a powerful integrative framework to understand and interpret the roles of proteins and peptides in diseases.

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Acknowledgments

This work was supported in part by the Marie Curie Actions—BCMolMed (FP7-PEOPLE-2012-ITN-EID).

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Authors and Affiliations

  1. Mosaiques-Diagnostics GmbH, Mellendorfer Straße 7-9, D-30625, Hannover, Germany

    Akshay Bhat

  2. Mosaiques diagnostics & therapeutics, Hannover, Germany

    Mohammed Dakna & Harald Mischak

Authors
  1. Akshay Bhat
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  2. Mohammed Dakna
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  3. Harald Mischak
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Corresponding author

Correspondence to Akshay Bhat .

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Editors and Affiliations

  1. Biomedical Research Foundation, Academy of Athens, Athens, Greece

    Antonia Vlahou

  2. Biomedical Research Foundation, Academy of Athens, Athens, Greece

    Manousos Makridakis

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Bhat, A., Dakna, M., Mischak, H. (2015). Integrating Proteomics Profiling Data Sets: A Network Perspective. In: Vlahou, A., Makridakis, M. (eds) Clinical Proteomics. Methods in Molecular Biology, vol 1243. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1872-0_14

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  • DOI: https://doi.org/10.1007/978-1-4939-1872-0_14

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-1871-3

  • Online ISBN: 978-1-4939-1872-0

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