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Method for Stimulation of Hippocampal Neurogenesis by Transient Microneedle Insertion

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Neural Stem Cells

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1919))

Abstract

Brief stereotaxic insertion and removal of a microneedle into the hippocampus of mice result in stimulation of hippocampal neurogenesis. This approach has been previously applied to a mouse model of Alzheimer’s disease (Song et al., Cell Transplant 25:1853–1861, 2016). Further studies of fundamental cellular mechanisms of the brain’s response to micro-injury will be useful for investigation of potential neuroprotective and deleterious effects of targeted microlesions and deep brain stimulation in neurodegenerative diseases.

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Acknowledgments

Supported in part by VA Merit Grant and Ellis Research Fund.

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Authors and Affiliations

  1. Department of Neurology and Neurosurgery, University of South Florida, Tampa, FL, USA

    Shijie Song, Xiaoyung Kong & Juan Sanchez-Ramos

  2. Department of Neurology, James A. Haley VAH Research Service, University of South Florida, Tampa, FL, USA

    Shijie Song & Juan Sanchez-Ramos

  3. College of Medicine Neurology, University of South Florida, Tampa, FL, USA

    Xiaoyung Kong

  4. College of Medicine Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL, USA

    Xiaoyung Kong

Authors
  1. Shijie Song
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  2. Xiaoyung Kong
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  3. Juan Sanchez-Ramos
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Corresponding authors

Correspondence to Shijie Song or Juan Sanchez-Ramos .

Editor information

Editors and Affiliations

  1. Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA

    Marcel M. Daadi

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Song, S., Kong, X., Sanchez-Ramos, J. (2019). Method for Stimulation of Hippocampal Neurogenesis by Transient Microneedle Insertion. In: Daadi, M. (eds) Neural Stem Cells. Methods in Molecular Biology, vol 1919. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-9007-8_18

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  • DOI: https://doi.org/10.1007/978-1-4939-9007-8_18

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-9005-4

  • Online ISBN: 978-1-4939-9007-8

  • eBook Packages: Springer Protocols

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