Volume 32, Issue 9

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September 2023

Special Issue in Honor of Prof. Thomas A. Baillie for His Many Contributions to Drug Metabolism and Drug Discovery

Issue Editors:

Cyrus Khojasteh-Bakht,
Mark Grillo,
Kaushik Mitra

13 articles in this issue

Dedication to Dr. Thomas Baillie in recognition of his scientific career
Cyrus Khojasteh-Bakht
Mark Grillo
Kaushik Mitra
Editorial 16 September 2023 Pages: 1851 - 1852
Part of 1 collection:

Special Issue in Honor of Prof. Thomas A. Baillie
The pyridazine heterocycle in molecular recognition and drug discovery
Nicholas A. Meanwell
Review Article 15 March 2023 Pages: 1853 - 1921
Part of 2 collections:

Drug Design reviews

Special Issue in Honor of Prof. Thomas A. Baillie
Utilizing mechanistic organic chemistry training to study drug metabolism in preclinical drug discovery/development
Deepak Dalvie
Amit S. Kalgutkar
Review Article 07 June 2023 Pages: 1922 - 1932
Part of 2 collections:

Drug Design reviews

Special Issue in Honor of Prof. Thomas A. Baillie
A MIST conception: what has been learned from twenty years of human metabolite safety assessment?
Debra Luffer-Atlas
R. Scott Obach
Dennis A. Smith
Review Article 13 June 2023 Pages: 1933 - 1949
Part of 2 collections:

Drug Design reviews

Special Issue in Honor of Prof. Thomas A. Baillie
What’s been Hapten-ing over the last 88 years?
Paul Thomson
Sean Hammond
Dean J. Naisbitt
Review Article Open access 15 June 2023 Pages: 1950 - 1971
Part of 1 collection:

Special Issue in Honor of Prof. Thomas A. Baillie
Glutathione and glutathione disulfide – their biomedical and pharmaceutical applications
Xiangming Guan
Review Article 28 July 2023 Pages: 1972 - 1994
Part of 2 collections:

Prodrugs

Special Issue in Honor of Prof. Thomas A. Baillie
A review of the mechanisms of valproate-induced liver injury with an emphasis on the role of reactive metabolites discovered by Tom Baillie
Jack Uetrecht
Review Article 07 August 2023 Pages: 1995 - 2000
Part of 1 collection:

Special Issue in Honor of Prof. Thomas A. Baillie
A review of the synthesis, bioanalysis, and chemical reactivity of xenobiotic acyl-coenzyme a thioesters
Christian Skonberg
Jørgen Olsen
Review Article 10 August 2023 Pages: 2001 - 2015
Part of 1 collection:

Special Issue in Honor of Prof. Thomas A. Baillie
The past decade of Genentech experience in elucidation of novel reaction mechanisms in drug metabolism
Cyrus Khojasteh
Jasleen K. Sodhi
Donglu Zhang
Review Article 18 August 2023 Pages: 2016 - 2033
Part of 2 collections:

Drug Design reviews

Special Issue in Honor of Prof. Thomas A. Baillie
Minimizing the DILI potential of carboxylic acid-containing drugs: a perspective
Lars Weidolf
Ian Wilson
Review Article Open access 09 September 2023 Pages: 2034 - 2047
Part of 1 collection:

Special Issue in Honor of Prof. Thomas A. Baillie
Stable isotope applications in drug development and the elucidation of mechanisms of drug metabolism
Rheem A. Totah
Allan E. Rettie
Review Article 29 August 2023 Pages: 2048 - 2057
Part of 1 collection:

Special Issue in Honor of Prof. Thomas A. Baillie
Acyl-CoA thioesters as chemically-reactive intermediates of carboxylic acid-containing drugs
Mark P. Grillo
Chunze Li
Leslie Z. Benet
Review Article 26 August 2023 Pages: 2058 - 2070
Part of 1 collection:

Special Issue in Honor of Prof. Thomas A. Baillie
The metabolic fate of izencitinib, a gut-selective pan-JAK inhibitor, in humans. Identification of unusual fecal metabolites and implications for MIST evaluation
Suresh Yeola
Ilaria Badagnani
David L. Bourdet
Original Research Article 09 September 2023 Pages: 2071 - 2088
Part of 1 collection:

Special Issue in Honor of Prof. Thomas A. Baillie

Volume 32, Issue 9

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