Collection
Special Issue in Honor of Prof. Thomas A. Baillie
- Submission status
- Closed
Special Issue in honor of Prof. Thomas A. Baillie for his many contributions to drug metabolism and drug discovery
Editors
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Cyrus Khojasteh-Bakht
Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA 94080, USA
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Mark Grillo
Drug Metabolism and Pharmacokinetics, Cytokinetics, Inc., South San Francisco, CA 94080, USA
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Kaushik Mitra
Discovery, Product Development & Supply, Preclinical Sciences & Translational Safety, Drug Metabolism and Pharmacokinetics, Janssen Pharmaceuticals, Springhouse, PA 19477, USA
Articles (13 in this collection)
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Minimizing the DILI potential of carboxylic acid-containing drugs: a perspective
Authors
- Lars Weidolf
- Ian Wilson
- Content type: Review Article
- Open Access
- Published: 09 September 2023
- Pages: 2034 - 2047
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The metabolic fate of izencitinib, a gut-selective pan-JAK inhibitor, in humans. Identification of unusual fecal metabolites and implications for MIST evaluation
Authors (first, second and last of 10)
- Suresh Yeola
- Ilaria Badagnani
- David L. Bourdet
- Content type: Original Research Article
- Published: 09 September 2023
- Pages: 2071 - 2088
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Stable isotope applications in drug development and the elucidation of mechanisms of drug metabolism
Authors
- Rheem A. Totah
- Allan E. Rettie
- Content type: Review Article
- Published: 29 August 2023
- Pages: 2048 - 2057
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Acyl-CoA thioesters as chemically-reactive intermediates of carboxylic acid-containing drugs
Authors
- Mark P. Grillo
- Chunze Li
- Leslie Z. Benet
- Content type: Review Article
- Published: 26 August 2023
- Pages: 2058 - 2070
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The past decade of Genentech experience in elucidation of novel reaction mechanisms in drug metabolism
Authors (first, second and last of 4)
- Cyrus Khojasteh
- Jasleen K. Sodhi
- Donglu Zhang
- Content type: Review Article
- Published: 18 August 2023
- Pages: 2016 - 2033
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A review of the synthesis, bioanalysis, and chemical reactivity of xenobiotic acyl-coenzyme a thioesters
Authors
- Christian Skonberg
- Jørgen Olsen
- Content type: Review Article
- Published: 10 August 2023
- Pages: 2001 - 2015
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A review of the mechanisms of valproate-induced liver injury with an emphasis on the role of reactive metabolites discovered by Tom Baillie
Authors
- Jack Uetrecht
- Content type: Review Article
- Published: 07 August 2023
- Pages: 1995 - 2000
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Glutathione and glutathione disulfide – their biomedical and pharmaceutical applications
Authors
- Xiangming Guan
- Content type: Review Article
- Published: 28 July 2023
- Pages: 1972 - 1994
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What’s been Hapten-ing over the last 88 years?
Authors (first, second and last of 4)
- Paul Thomson
- Sean Hammond
- Dean J. Naisbitt
- Content type: Review Article
- Open Access
- Published: 15 June 2023
- Pages: 1950 - 1971
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A MIST conception: what has been learned from twenty years of human metabolite safety assessment?
Authors
- Debra Luffer-Atlas
- R. Scott Obach
- Dennis A. Smith
- Content type: Review Article
- Published: 13 June 2023
- Pages: 1933 - 1949
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Utilizing mechanistic organic chemistry training to study drug metabolism in preclinical drug discovery/development
Authors
- Deepak Dalvie
- Amit S. Kalgutkar
- Content type: Review Article
- Published: 07 June 2023
- Pages: 1922 - 1932
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The pyridazine heterocycle in molecular recognition and drug discovery
Authors
- Nicholas A. Meanwell
- Content type: Review Article
- Published: 15 March 2023
- Pages: 1853 - 1921