Volume 31, Issue 10

Search all Medicinal Chemistry Research articles

October 2022

Special issue of Medicinal Chemistry Research in honor of Professor Edmond J. LaVoie

Issue Editors:

Matthew Moschitto,
Alexander L. Ruchelman,
Longqin Hu

15 articles in this issue

Special issue of Medicinal Chemistry Research in honor of Professor Edmond J. LaVoie
Alexander L. Ruchelman
Longqin Hu
Editorial 06 September 2022 Pages: 1621 - 1622
Part of 1 collection:

Special Issue in honor of Prof. Edmond J. LaVoie
A case history in natural product-based drug discovery: discovery of vorapaxar (Zontivity™)
Samuel Chackalamannil
Review Article 02 September 2022 Pages: 1623 - 1636
Part of 2 collections:

New Drug Discovery Minireviews

Special Issue in honor of Prof. Edmond J. LaVoie
The history, mechanism, and perspectives of nirmatrelvir (PF-07321332): an orally bioavailable main protease inhibitor used in combination with ritonavir to reduce COVID-19-related hospitalizations
Ryan P. Joyce
Vivian W. Hu
Jun Wang
Review Article 30 August 2022 Pages: 1637 - 1646
Part of 5 collections:

Most Cited Articles in Medicinal Chemistry Research, 2022

Drug Design reviews

SARS-CoV-2

Special Issue in honor of Prof. Edmond J. LaVoie

New Drug Discovery Minireviews
Discovery of mobocertinib, a new irreversible tyrosine kinase inhibitor indicated for the treatment of non-small-cell lung cancer harboring EGFR exon 20 insertion mutations
Jun Wang
Daniel Lam
Longqin Hu
Review Article 01 September 2022 Pages: 1647 - 1662
Part of 3 collections:

New Drug Discovery Minireviews

Drug Design reviews

Special Issue in honor of Prof. Edmond J. LaVoie
Antimicrobial activity of quaternary ammonium salts: structure-activity relationship
Mallikarjuna N. Nadagouda
Pooja Vijayasarathy
Changseok Han
Review Paper 02 July 2022 Pages: 1663 - 1678
Part of 3 collections:

Drug Design reviews

Most Cited Articles in Medicinal Chemistry Research, 2022

Special Issue in honor of Prof. Edmond J. LaVoie
Novel MreB inhibitors with antibacterial activity against Gram (-) bacteria
Hye Yeon Sagong
Jesus D. Rosado-Lugo
Edmond J. LaVoie
Original Research 14 September 2022 Pages: 1679 - 1704
Part of 1 collection:

Special Issue in honor of Prof. Edmond J. LaVoie
Combination with a FtsZ inhibitor potentiates the in vivo efficacy of oxacillin against methicillin-resistant Staphylococcus aureus
Malvika Kaul
Edgar Ferrer-González
Daniel S. Pilch
Original Research 05 September 2022 Pages: 1705 - 1715
Part of 2 collections:

Prodrugs

Special Issue in honor of Prof. Edmond J. LaVoie
Design, synthesis, and structure–activity relationships of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as inhibitors of the programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) immune checkpoint pathway
Jeffrey Yang
Subhadwip Basu
Longqin Hu
Original Research 14 July 2022 Pages: 1716 - 1739
Part of 2 collections:

Protein-protein interactions

Special Issue in honor of Prof. Edmond J. LaVoie
Bio-guided isolation of anti-Alzheimer’s compounds from Phyllanthus niruri and role of niruriflavone in the reversal of aluminum chloride-induced neurobehavioral and biochemical changes in an animal model
Gayathri Rajamanickam
Manju SL
Original Research 24 August 2022 Pages: 1740 - 1753
Part of 1 collection:

Special Issue in honor of Prof. Edmond J. LaVoie
Development of new donepezil analogs: synthesis, biological screening and in silico study rational
Zeinab Mahmoud
Hadeer S. Sayed
Khaled O. Mohamed
Original Paper Open access 04 August 2022 Pages: 1754 - 1770
Part of 1 collection:

Special Issue in honor of Prof. Edmond J. LaVoie
Design, synthesis and molecular docking studies of novel benzimidazole-1,3,4-oxadiazole hybrids for their carbonic anhydrase inhibitory and antioxidant effects
Kaan Küçükoğlu
Ulviye Acar Çevik
Zafer Asım Kaplancıklı
Original Research 08 August 2022 Pages: 1771 - 1782
Part of 1 collection:

Special Issue in honor of Prof. Edmond J. LaVoie
Synthesis, characterization and biological evaluation of Bis-benzimidazolium salts and their silver(I)-N-heterocyclic carbene complexes
Rana Yasir Nadeem
Munazzah Yaqoob
Muhammad Adnan Iqbal
Original Research 08 August 2022 Pages: 1783 - 1791
Part of 1 collection:

Special Issue in honor of Prof. Edmond J. LaVoie
Exploring thiazole-linked thioureas using alkaline phosphatase assay, biochemical evaluation, computational analysis and structure–activity relationship (SAR) studies
Sajid Ali Channar
Pervaiz Ali Channar
Parvez Ali Mahesar
Original Research 13 August 2022 Pages: 1792 - 1802
Part of 1 collection:

Special Issue in honor of Prof. Edmond J. LaVoie
Discovery of α-methylene-γ-lactone-δ-epoxy derivatives with anti-cancer activity: synthesis, SAR study, and biological activity
Jie Ren
Pengchao Yu
Kun Hu
Original Research 18 August 2022 Pages: 1803 - 1817
Part of 1 collection:

Special Issue in honor of Prof. Edmond J. LaVoie
Novel 2-aminopyrimidine Schiff bases as possible GABA-AT inhibitors: molecular docking, MAOS, and pharmacological screening
Poonam Jaisal
Gul Naz Fatima
Shailendra K. Saraf
Original Research 26 August 2022 Pages: 1818 - 1829

Volume 31, Issue 10

Special issue of Medicinal Chemistry Research in honor of Professor Edmond J. LaVoie

A case history in natural product-based drug discovery: discovery of vorapaxar (Zontivity™)

The history, mechanism, and perspectives of nirmatrelvir (PF-07321332): an orally bioavailable main protease inhibitor used in combination with ritonavir to reduce COVID-19-related hospitalizations

Discovery of mobocertinib, a new irreversible tyrosine kinase inhibitor indicated for the treatment of non-small-cell lung cancer harboring EGFR exon 20 insertion mutations

Antimicrobial activity of quaternary ammonium salts: structure-activity relationship

Novel MreB inhibitors with antibacterial activity against Gram (-) bacteria

Combination with a FtsZ inhibitor potentiates the in vivo efficacy of oxacillin against methicillin-resistant Staphylococcus aureus

Design, synthesis, and structure–activity relationships of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as inhibitors of the programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) immune checkpoint pathway

Bio-guided isolation of anti-Alzheimer’s compounds from Phyllanthus niruri and role of niruriflavone in the reversal of aluminum chloride-induced neurobehavioral and biochemical changes in an animal model

Development of new donepezil analogs: synthesis, biological screening and in silico study rational

Design, synthesis and molecular docking studies of novel benzimidazole-1,3,4-oxadiazole hybrids for their carbonic anhydrase inhibitory and antioxidant effects

Synthesis, characterization and biological evaluation of Bis-benzimidazolium salts and their silver(I)-N-heterocyclic carbene complexes

Exploring thiazole-linked thioureas using alkaline phosphatase assay, biochemical evaluation, computational analysis and structure–activity relationship (SAR) studies

Discovery of α-methylene-γ-lactone-δ-epoxy derivatives with anti-cancer activity: synthesis, SAR study, and biological activity

Novel 2-aminopyrimidine Schiff bases as possible GABA-AT inhibitors: molecular docking, MAOS, and pharmacological screening

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