Application of Solubility and Dissolution Profile Comparison for Prediction of Gastric pH-Mediated Drug-Drug Interactions Lei MiaoFang WuPaul Seo Research Article 14 February 2022 Article: 35
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The Perspective of DMPK on Recombinant Adeno-Associated Virus-Based Gene Therapy: Past Learning, Current Support, and Future Contribution Nancy ChenKefeng SunCindy Q. Xia Review Article Open access 31 January 2022 Article: 31
Nfe2l2 Regulates Metabolic Rewiring and Epigenetic Reprogramming in Mediating Cancer Protective Effect by Fucoxanthin Lujing WangRenyi WuAh-Ng Kong Research Article 18 January 2022 Article: 30
Correction to: Quantitative Systems Pharmacology Modeling of Avadomide-Induced Neutropenia Enables Virtual Clinical Dose and Schedule Finding Studies Roberto A. AbbiatiMichael PourdehnadAlexander V. Ratushny Correction 14 January 2022 Article: 29
In Vitro to In Vivo Extrapolation Linked to Physiologically Based Pharmacokinetic Models for Assessing the Brain Drug Disposition Yukiko MurataSibylle NeuhoffKayode Ogungbenro Review Article Open access 13 January 2022 Article: 28
Performance Evaluation of Montelukast Pediatric Formulations: Part II — a PBPK Modelling Approach Mariana GuimarãesMaria VertzoniNikoletta Fotaki Research Article Open access 10 January 2022 Article: 27
Performance Evaluation of Montelukast Pediatric Formulations: Part I—Age-Related In Vitro Conditions Mariana GuimarãesPascal SomvilleNikoletta Fotaki Research Article Open access 10 January 2022 Article: 26
Predicting Food Effects: Are We There Yet? Arian Emami Riedmaier Commentary 10 January 2022 Article: 25
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A Full Evaporation Static Headspace Gas Chromatography Method with Nitrogen Phosphorous Detection for Ultrasensitive Analysis of Semi-volatile Nitrosamines in Pharmaceutical Products Jinjian ZhengChristine L. KirkpatrickMark D. Mowery Research Article Open access 06 January 2022 Article: 23
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Proof of Concept in Assignment of Within-Subject Variability During Virtual Bioequivalence Studies: Propagation of Intra-Subject Variation in Gastrointestinal Physiology Using Physiologically Based Pharmacokinetic Modeling Margareta BegoNikunjkumar PatelAmin Rostami-Hodjegan Research Article Open access 05 January 2022 Article: 21
Evaluation of Excipient Risk in BCS Class I and III Biowaivers Melissa MetryJames E. Polli Review Article Open access 05 January 2022 Article: 20
Machine Learning and Artificial Intelligence in Pharmaceutical Research and Development: a Review Sheela KolluriJianchang LinWenwen Zhang Review Article 04 January 2022 Article: 19
Zwitterionic Polymer Coatings Enhance Gold Nanoparticle Stability and Uptake in Various Biological Environments Benjamin M. KingJennifer Fiegel Research Article 04 January 2022 Article: 18
Dissolution Challenges Associated with the Surface pH of Drug Particles: Integration into Mechanistic Oral Absorption Modeling Bart HensNidhi SeegobinGordon L. Amidon Research Article 04 January 2022 Article: 17
Exploring the Relationship of Drug BCS Classification, Food Effect, and Gastric pH-Dependent Drug Interactions Katie OwensSophie ArgonIsabelle Ragueneau-Majlessi Research Article 27 December 2021 Article: 16
Assessment of Functional Characterization and Comparability of Biotherapeutics: a Review Rozaleen DashSumit Kumar SinghAnurag S. Rathore Review Article 20 December 2021 Article: 15
Reactive Oxygen Species–Responsive Celastrol-Loaded Bilirubin Nanoparticles for the Treatment of Rheumatoid Arthritis Xuan ZhaoChengyuan HuangZongning Yin Research Article 14 December 2021 Article: 14
PBPK Simulation-Based Evaluation of Ganciclovir Crystalluria Risk Factors: Effect of Renal Impairment, Old Age, and Low Fluid Intake Daniel ScotcherAleksandra Galetin Research Article Open access 14 December 2021 Article: 13
Predicting the Drug–Drug Interaction Mediated by CYP3A4 Inhibition: Method Development and Performance Evaluation Hong-can RenYang SaiCheng-guang Yang Research Article 10 December 2021 Article: 12
Efficacy and Safety Exposure–Response Analysis of Loncastuximab Tesirine in Patients with B cell non-Hodgkin Lymphoma Brian HessWilliam TownsendJoseph Boni Research Article 10 December 2021 Article: 11
Comparison of Predictions by BCS, rDCS and Machine Learning for the Effect of Food on Oral Drug Absorption Based on Features Calculated In silico Yusuke HoshinoHideki YoshiokaAkihiro Hisaka Research Article 10 December 2021 Article: 10
Systematic Evaluation of the Effect of Formulation Variables on In Vitro Performance of Mometasone Furoate Suspension-Metered Dose Inhalers Sagar S. BachhavPoonam ShethGuenther Hochhaus Research Article 07 December 2021 Article: 9
Development of Lipidoid Nanoparticles for siRNA Delivery to Neural Cells Purva KhareKandarp M. DaveDevika S. Manickam Research Article 06 December 2021 Article: 8
A Novel Approach for Quantifying the Pharmacological Activity of T-Cell Engagers Utilizing In Vitro Time Course Experiments and Streamlined Data Analysis Arthur Van De VyverMiro EigenmannAntje-Christine Walz Research Article Open access 03 December 2021 Article: 7
Microfluidic-Generated Immunomodulatory Nanoparticles and Formulation-Dependent Effects on Lipopolysaccharide-Induced Macrophage Inflammation Nhu TruongSheneil K. BlackRyan M. Pearson Research Article 02 December 2021 Article: 6
Assessment of the Kochak-Benet Equation for Hepatic Clearance for the Parallel-Tube Model: Relevance of Classic Clearance Concepts in PK and PBPK William J. JuskoXiaonan Li Commentary 01 December 2021 Article: 5
Anti-drug Antibody Validation Testing and Reporting Harmonization Heather MylerJoão Pedras-VasconcelosMark Ware White Paper Open access 01 December 2021 Article: 4
Innovative Design and Analysis for PK/PD Biosimilar Bridging Studies with Multiple References Fuyu SongXin ZhengHongqiang Sun Research Article 30 November 2021 Article: 3
Navigating Through Cell-Based In vitro Models Available for Prediction of Intestinal Permeability and Metabolism: Are We Ready for 3D? Yesenia L. FrancoLais Da SilvaRodrigo Cristofoletti Commentary 22 November 2021 Article: 2
Correction to: Can Pharmacokinetic Studies Assess the Pulmonary Fate of Dry Powder Inhaler Formulations of Fluticasone Propionate? Günther HochhausMong-Jen ChenJürgen B. Bulitta Correction 22 November 2021 Article: 1