Theme: Integrating In Vitro Systems and Physiologically-Based Pharmacokinetics Modeling to Optimize Drug Product Development

In this topical collection (8 articles)

1. 

   Research Article

   Understanding In Vivo Dissolution of Immediate Release (IR) Solid Oral Drug Products Containing Weak Acid BCS Class 2 (BCS Class 2a) Drugs

   Min Li, Xinwen Zhang, Di Wu, Om Anand, Hansong Chen, Kimberly Raines… Article:113

2. Review Article

   In Vitro to In Vivo Extrapolation Linked to Physiologically Based Pharmacokinetic Models for Assessing the Brain Drug Disposition

   Yukiko Murata, Sibylle Neuhoff, Amin Rostami-Hodjegan, Hiroyuki Takita… Article:28

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3. Research Article

   Performance Evaluation of Montelukast Pediatric Formulations: Part II — a PBPK Modelling Approach

   Mariana Guimarães, Maria Vertzoni, Nikoletta Fotaki Article:27

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4. Research Article

   Performance Evaluation of Montelukast Pediatric Formulations: Part I—Age-Related In Vitro Conditions

   Mariana Guimarães, Pascal Somville, Maria Vertzoni, Nikoletta Fotaki Article:26

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5. 

   Commentary

   Predicting Food Effects: Are We There Yet?

   Arian Emami Riedmaier Article:25

6. Research Article

   Proof of Concept in Assignment of Within-Subject Variability During Virtual Bioequivalence Studies: Propagation of Intra-Subject Variation in Gastrointestinal Physiology Using Physiologically Based Pharmacokinetic Modeling

   Margareta Bego, Nikunjkumar Patel, Rodrigo Cristofoletti… Article:21

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7. 

   Research Article

   Dissolution Challenges Associated with the Surface pH of Drug Particles: Integration into Mechanistic Oral Absorption Modeling

   Bart Hens, Nidhi Seegobin, Marival Bermejo, Yasuhiro Tsume… Article:17

8. Commentary

   Navigating Through Cell-Based In vitro Models Available for Prediction of Intestinal Permeability and Metabolism: Are We Ready for 3D?

   Yesenia L. Franco, Lais Da Silva, Rodrigo Cristofoletti Article:2

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