The Two Main Goals of Bioequivalence Studies Laszlo EndrenyiHenning H. BlumeLaszlo Tothfalusi Commentary 02 February 2017 Pages: 885 - 890
Microdialysis: the Key to Physiologically Based Model Prediction of Human CNS Target Site Concentrations Yumi YamamotoMeindert DanhofElizabeth C. M. de Lange Review Article Open access 09 March 2017 Pages: 891 - 909
Hypoxic Stress and Inflammatory Pain Disrupt Blood-Brain Barrier Tight Junctions: Implications for Drug Delivery to the Central Nervous System Jeffrey J. LochheadPatrick T. RonaldsonThomas P. Davis Review Article 28 March 2017 Pages: 910 - 920
Blood-Brain Barriers in Obesity Elizabeth M. RheaTherese S. SalamehWilliam A. Banks Review Article 10 April 2017 Pages: 921 - 930
Functional Expression of P-glycoprotein and Organic Anion Transporting Polypeptides at the Blood-Brain Barrier: Understanding Transport Mechanisms for Improved CNS Drug Delivery? Wazir AbdullahiThomas P. DavisPatrick T. Ronaldson Review Article 26 April 2017 Pages: 931 - 939
Neurovascular Alterations in Alzheimer’s Disease: Transporter Expression Profiles and CNS Drug Access Mitchell P. McInerneyJennifer L. ShortJoseph A. Nicolazzo Review Article 01 May 2017 Pages: 940 - 956
Blood-Brain Barrier Protection as a Therapeutic Strategy for Acute Ischemic Stroke Ali Ehsan SifatBhuvaneshwar VaidyaThomas J. Abbruscato Review Article 08 May 2017 Pages: 957 - 972
Breaking Bad: the Structure and Function of the Blood-Brain Barrier in Epilepsy Hadas HanAniv MannSara Eyal Review Article 26 May 2017 Pages: 973 - 988
Evolution of Choice of Solubility and Dissolution Media After Two Decades of Biopharmaceutical Classification System Nadia Bou-ChacraKatherine Jasmine Curo MeloRaimar Löbenberg Review Article Open access 17 May 2017 Pages: 989 - 1001
QSP Toolbox: Computational Implementation of Integrated Workflow Components for Deploying Multi-Scale Mechanistic Models Yougan ChengCraig J. ThalhauserBrian J. Schmidt Tutorial Open access 24 May 2017 Pages: 1002 - 1016
Controlled Release of Vanadium from a Composite Scaffold Stimulates Mesenchymal Stem Cell Osteochondrogenesis S. D. SchusslerK. UskeTreena Livingston Arinzeh Research Article 22 March 2017 Pages: 1017 - 1028
Controlled Ion Release from Novel Polyester/Ceramic Composites Enhances Osteoinductivity Soheila Ali Akbari GhavimiRama Rao TataBret D. Ulery Research Article 11 May 2017 Pages: 1029 - 1044
Physiologically Based Pharmacokinetic and Absorption Modeling for Osmotic Pump Products Zhanglin NiArjang TalattofXinyuan Zhang Research Article 29 March 2017 Pages: 1045 - 1053
Application of a PK-PD Modeling and Simulation-Based Strategy for Clinical Translation of Antibody-Drug Conjugates: a Case Study with Trastuzumab Emtansine (T-DM1) Aman P. SinghDhaval K. Shah Research Article 03 April 2017 Pages: 1054 - 1070
How Has CDER Prepared for the Nano Revolution? A Review of Risk Assessment, Regulatory Research, and Guidance Activities Katherine M. TynerNan ZhengCelia N. Cruz Regulatory Note 18 April 2017 Pages: 1071 - 1083
The impact of gastric pH, volume, and emptying on the food effect of ziprasidone oral absorption Steven C SuttonRichard NauseKuan Gandelman Research Article 20 March 2017 Pages: 1084 - 1090
Dissolution comparisons using a Multivariate Statistical Distance (MSD) test and a comparison of various approaches for calculating the measurements of dissolution profile comparison J-M. CardotB. RoudierH. Schütz Research Article 28 March 2017 Pages: 1091 - 1101
In Vitro and In Vivo Metabolite Identification Studies for the New Synthetic Opioids Acetylfentanyl, Acrylfentanyl, Furanylfentanyl, and 4-Fluoro-Isobutyrylfentanyl Shimpei WatanabeSvante VikingssonAriane Wohlfarth Research Article 05 April 2017 Pages: 1102 - 1122
Site Selection: a Case Study in the Identification of Optimal Cysteine Engineered Antibody Drug Conjugates L. Nathan TumeyFengping LiLioudmila Tchistiakova Research Article 24 April 2017 Pages: 1123 - 1135
Infliximab Maintenance Dosing in Inflammatory Bowel Disease: an Example for In Silico Assessment of Adaptive Dosing Strategies Jessica WojciechowskiRichard N. UptonDavid J. R. Foster Research Article 25 April 2017 Pages: 1136 - 1147
Metabolic Profile of Synthetic Cannabinoids 5F-PB-22, PB-22, XLR-11 and UR-144 by Cunninghamella elegans Shimpei WatanabeUnnikrishnan KuzhiumparambilShanlin Fu Research Article 28 April 2017 Pages: 1148 - 1162
Minipig and Human Metabolism of Aldehyde Oxidase Substrates: In Vitro–In Vivo Comparisons David J. WilkinsonRosalind L. SouthallMichael B. Otteneder Research Article 04 May 2017 Pages: 1163 - 1174
Controlled Release of Second Generation mTOR Inhibitors to Restrain Inflammation in Primary Immune Cells Emily A. GosselinLisa H. TostanoskiChristopher M. Jewell Research Article 08 May 2017 Pages: 1175 - 1185
Mechanistic Modeling of the Pharmacodynamic and Pharmacokinetic Relationship of Tissue Factor Pathway Inhibitor-Neutralizing Antibody (BAY 1093884) in Cynomolgus Monkeys Jian-Ming GuXiao-Yan ZhaoMaria Koellnberger Research Article Open access 17 May 2017 Pages: 1186 - 1195
Distribution of Exogenous and Endogenous CYP3A Markers and Related Factors in Healthy Males and Females Jieon LeeAndrew HyoungJin KimJoo-Youn Cho Research Article 18 May 2017 Pages: 1196 - 1204
Incorporation of the Time-Varying Postprandial Increase in Splanchnic Blood Flow into a PBPK Model to Predict the Effect of Food on the Pharmacokinetics of Orally Administered High-Extraction Drugs Rachel H. RoseDavid B. TurnerMasoud Jamei Research Article 19 May 2017 Pages: 1205 - 1217
Ultra-Sensitive Measurement of IL-17A and IL-17F in Psoriasis Patient Serum and Skin Catherine SoderstromGabriel BersteinStephanie Fraser Research Article 22 May 2017 Pages: 1218 - 1222
Development and Characterization of a Neutralizing Anti-idiotype Antibody Against Mirvetuximab for Analysis of Clinical Samples Sven LoebrichMingfang ShenYiwei Zhao Research Article 22 May 2017 Pages: 1223 - 1234
Integrated In Silico Fragment-Based Drug Design: Case Study with Allosteric Modulators on Metabotropic Glutamate Receptor 5 Yuemin BianZhiwei FengXiang-Qun Xie Research Article 30 May 2017 Pages: 1235 - 1248
Erratum to: Microdialysis: the Key to Physiologically Based Model Prediction of Human CNS Target Site Concentrations Yumi YamamotoMeindert DanhofElizabeth C. M. de Lange Erratum 09 May 2017 Pages: 1249 - 1252