Theme: Systems Pharmacokinetics Models for Antibody-Drug Conjugates

ISSN: 1550-7416 (Online)

In this topical collection (8 articles)

  1. No Access

    Research Article

    Antibody Coadministration as a Strategy to Overcome Binding-Site Barrier for ADCs: a Quantitative Investigation

    Aman P. Singh, Leiming Guo, Ashwni Verma, Gloria Gao-Li Wong… Article:28

  2. No Access

    Research Article

    Development and Translational Application of an Integrated, Mechanistic Model of Antibody-Drug Conjugate Pharmacokinetics

    Siddharth Sukumaran, Crystal Zhang, Douglas D. Leipold, Ola M. Saad… Pages 130-140

  3. No Access

    Research Article

    Determination of Cellular Processing Rates for a Trastuzumab-Maytansinoid Antibody-Drug Conjugate (ADC) Highlights Key Parameters for ADC Design

    Katie F. Maass, Chethana Kulkarni, Alison M. Betts, K. Dane Wittrup Pages 635-646

  4. No Access

    Research Article

    Evolution of Antibody-Drug Conjugate Tumor Disposition Model to Predict Preclinical Tumor Pharmacokinetics of Trastuzumab-Emtansine (T-DM1)

    Aman P. Singh, Katie F. Maass, Alison M. Betts, K. Dane Wittrup… Pages 861-875

  5. No Access

    Research Article

    Application of a PK-PD Modeling and Simulation-Based Strategy for Clinical Translation of Antibody-Drug Conjugates: a Case Study with Trastuzumab Emtansine (T-DM1)

    Aman P. Singh, Dhaval K. Shah Pages 1054-1070

  6. No Access

    Research Article

    Preclinical to Clinical Translation of Antibody-Drug Conjugates Using PK/PD Modeling: a Retrospective Analysis of Inotuzumab Ozogamicin

    Alison M. Betts, Nahor Haddish-Berhane, John Tolsma, Paul Jasper… Pages 1101-1116

  7. No Access

    Research Article

    Multiscale Modeling of Antibody-Drug Conjugates: Connecting Tissue and Cellular Distribution to Whole Animal Pharmacokinetics and Potential Implications for Efficacy

    Cornelius Cilliers, Hans Guo, Jianshan Liao, Nikolas Christodolu… Pages 1117-1130

  8. No Access

    Research Article

    Development of a Translational Physiologically Based Pharmacokinetic Model for Antibody-Drug Conjugates: a Case Study with T-DM1

    Antari Khot, Jay Tibbitts, Dan Rock, Dhaval K. Shah Pages 1715-1734