Defining Patient Centric Pharmaceutical Drug Product Design Sven StegemannRobert L. TernikDiana A. van Riet-Nales White Paper Open access 17 June 2016 Pages: 1047 - 1055
Recommendations on the Development of a Bioanalytical Assay for 4β-Hydroxycholesterol, an Emerging Endogenous Biomarker of CYP3A Activity Anne-Françoise AubryBrian DeanZiping Yang Commentary 27 June 2016 Pages: 1056 - 1066
Key to Opening Kidney for In Vitro–In Vivo Extrapolation Entrance in Health and Disease: Part I: In Vitro Systems and Physiological Data Daniel ScotcherChristopher JonesAleksandra Galetin Review Article Open access 30 June 2016 Pages: 1067 - 1081
Key to Opening Kidney for In Vitro-In Vivo Extrapolation Entrance in Health and Disease: Part II: Mechanistic Models and In Vitro-In Vivo Extrapolation Daniel ScotcherChristopher JonesAmin Rostami-Hodjegan Review Article Open access 09 August 2016 Pages: 1082 - 1094
Lipophilicity in Drug Development: Too Much or Not Enough? Christel A. S. BergströmMehran Yazdanian Meeting Report 08 July 2016 Pages: 1095 - 1100
Preclinical to Clinical Translation of Antibody-Drug Conjugates Using PK/PD Modeling: a Retrospective Analysis of Inotuzumab Ozogamicin Alison M. BettsNahor Haddish-BerhaneTheodore R. Johnson Research Article 19 May 2016 Pages: 1101 - 1116
Multiscale Modeling of Antibody-Drug Conjugates: Connecting Tissue and Cellular Distribution to Whole Animal Pharmacokinetics and Potential Implications for Efficacy Cornelius CilliersHans GuoGreg M. Thurber Research Article 10 June 2016 Pages: 1117 - 1130
Investigation of Polymer-Surfactant and Polymer-Drug-Surfactant Miscibility for Solid Dispersion Suhas G. GumasteSimerdeep Singh GuptaAbu T. M. Serajuddin Research Article 14 June 2016 Pages: 1131 - 1143
Examining the Use of a Mechanistic Model to Generate an In Vivo/In Vitro Correlation: Journey Through a Thought Process Bipin MistryNikunjkumar PatelMarilyn N. Martinez Research Article 16 June 2016 Pages: 1144 - 1158
Understanding the Different Effects of Inhaler Design on the Aerosol Performance of Drug-Only and Carrier-Based DPI Formulations. Part 1: Grid Structure Cassandra Ming Shan LeungZhenbo TongHak-Kim Chan Research Article 09 May 2016 Pages: 1159 - 1167
Di-Peptide-Modified Gemini Surfactants as Gene Delivery Vectors: Exploring the Role of the Alkyl Tail in Their Physicochemical Behavior and Biological Activity Mays A. Al-DulaymiJackson M. ChitandaIldiko Badea Research Article 16 May 2016 Pages: 1168 - 1181
A Novel Physiology-Based Mathematical Model to Estimate Red Blood Cell Lifespan in Different Human Age Groups Guohua AnJohn A. WidnessPeter Veng-Pedersen Research Article 23 May 2016 Pages: 1182 - 1191
Clinical Predictors of Venetoclax Pharmacokinetics in Chronic Lymphocytic Leukemia and Non-Hodgkin’s Lymphoma Patients: a Pooled Population Pharmacokinetic Analysis Aksana K. JonesKevin J. FreiseAhmed Hamed Salem Research Article 27 May 2016 Pages: 1192 - 1202
Modeling the Disease Progression from Healthy to Overt Diabetes in ZDSD Rats Steve ChoyWillem de WinterMaria C Kjellsson Research Article 31 May 2016 Pages: 1203 - 1212
How Much Surface Coating of Hydrophobic Azithromycin Is Sufficient to Prevent Moisture-Induced Decrease in Aerosolisation of Hygroscopic Amorphous Colistin Powder? Qi (Tony) ZhouZhi Hui LohHak-Kim Chan Research Article 02 June 2016 Pages: 1213 - 1224
Influence of Miscibility of Protein-Sugar Lyophilizates on Their Storage Stability Maarten A. MensinkMatthew J. NethercottMichael J. Pikal Research Article Open access 14 June 2016 Pages: 1225 - 1232
Optimal Design for Informative Protocols in Xenograft Tumor Growth Inhibition Experiments in Mice Giulia LestiniFrance MentréPaolo Magni Research Article 15 June 2016 Pages: 1233 - 1243
The Impact of Model-Misspecification on Model Based Personalised Dosing David A. J. McDougallJennifer MartinBruce Green Research Article 15 June 2016 Pages: 1244 - 1253
Urinary 6β-Hydroxycortisol/Cortisol Ratio Most Highly Correlates With Midazolam Clearance Under Hepatic CYP3A Inhibition and Induction in Females: A Pharmacometabolomics Approach Kwang-Hee ShinLi Young AhnJoo-Youn Cho Research Article 17 June 2016 Pages: 1254 - 1261
Improvement of Parameter Estimations in Tumor Growth Inhibition Models on Xenografted Animals: Handling Sacrifice Censoring and Error Caused by Experimental Measurement on Larger Tumor Sizes Philippe B. PierrillasMichel TodEmilie Henin Research Article 21 June 2016 Pages: 1262 - 1272
Metabolic Profile of 3-Acetyl-11-Keto-β-Boswellic Acid and 11-Keto-β-Boswellic Acid in Human Preparations In Vitro, Species Differences, and Bioactivity Variation Yonglei CuiXiangge TianXiaochi Ma Research Article 21 June 2016 Pages: 1273 - 1288
In Vivo Exposure of Kaempferol Is Driven by Phase II Metabolic Enzymes and Efflux Transporters Liang ZhengLijun ZhuZhongqiu Liu Research Article 08 July 2016 Pages: 1289 - 1299
Feasibility of Singlet Analysis for Ligand Binding Assays: a Retrospective Examination of Data Generated Using the Gyrolab Platform Tracey H. ClarkPhillip D. YatesChad A. Ray Research Article 11 July 2016 Pages: 1300 - 1308
A Quantitative Review and Meta-Models of the Variability and Factors Affecting Oral Drug Absorption—Part I: Gastrointestinal pH Ahmad Y. AbuhelwaDavid J. R. FosterRichard N. Upton Research Article 05 August 2016 Pages: 1309 - 1321
A Quantitative Review and Meta-models of the Variability and Factors Affecting Oral Drug Absorption—Part II: Gastrointestinal Transit Time Ahmad Y. AbuhelwaDavid J. R. FosterRichard N. Upton Research Article 20 July 2016 Pages: 1322 - 1333