Abstract
With the discovery of an increasing number of biologically active peptides and peptide mimetics (1–3), there is a pressing need for the development of strategies to deliver these biologically active compounds to the desired site of action. The preceding two chapters have described two methods of making esterase-sensitive cyclic prodrugs of peptides. In this chapter, we wish to describe a third method of making esterase-sensitive cyclic prodrugs of peptides using DADLE, an opioid peptide (4–7), as an example.
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© 1999 Humana Press Inc., Totowa, NJ
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Wang, B., Shan, D., Wang, W., Zhang, H., Gudmundsson, O., Borchardt, R.T. (1999). Synthesis of Coumarin-Based, Esterase-Sensitive Cyclic Prodrugs of Opioid Peptides with Enhanced Membrane Permeability and Enzymatic Stability. In: Kazmierski, W.M. (eds) Peptidomimetics Protocols. Methods in Molecular Medicine™, vol 23. Humana Press. https://doi.org/10.1385/0-89603-517-4:71
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DOI: https://doi.org/10.1385/0-89603-517-4:71
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