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Table of contents

  1. Front Matter
    Pages i-xxx
  2. Sanjeev Gangwar, Giovanni M. Pauletti, Teruna J. Siahaan, Valentino J. Stella, Ronald T. Borchardt
    Pages 37-51
  3. Binghe Wang, Daxian Shan, Wei Wang, Huijuan Zhang, Olafur Gudmundsson, Ronald T. Borchardt
    Pages 71-85
  4. Hyunsoo Han, Juyoung Yoon, Kim D. Janda
    Pages 87-102
  5. Robert V. Hoffman, Junhua Tao
    Pages 103-124
  6. Stephen Hanessian, Grant McNaughton-Smith
    Pages 161-174
  7. Debra S. Perlow, Roger M. Freidinger
    Pages 209-225
  8. Yves Le Merrer, Lydie Poitout, Jean-Claude Depezay
    Pages 227-257
  9. Yvette M. Fobian, Kevin D. Moeller
    Pages 259-279
  10. Wieslaw M. Kazmierski, Paul C. Fritch
    Pages 281-291
  11. Dirk Tourwé, Koen Iterbeke, Wieslaw M. Kazmierski, Géza Tóth
    Pages 321-338
  12. J. T. Welch, T. Allmendinger
    Pages 357-384
  13. James C. Marsters Jr., Thomas E. Rawson
    Pages 385-396
  14. Michael C. Hillier, Stephen F. Martin
    Pages 397-406
  15. Michael P. Dwyer, Stephen F. Martin
    Pages 407-416
  16. Janusz Zabrocki, Garland R. Marshall
    Pages 417-436
  17. David B. Berkowitz, Jill M. McFadden, Marianne K. Smith, Michelle L. Pedersen
    Pages 467-488
  18. Kimberly S. Para, Tomi K. Sawyer
    Pages 513-526
  19. Brian S. Fulton, Alan P. Kaplan, Joseph C. Hogan Jr., Steven L. Gallion
    Pages 527-537
  20. Back Matter
    Pages 539-549

About this book

Introduction

In Peptidomimetics Protocols, Wieslaw Kazmierski assembles a state-of-the-art collection of detailed synthetic procedures that lead to a variety of scaffolds, turn mimetics, peptide-bond replacements, and enzyme inhibitors. Topics range from syntheses of unusual amino acids, to the use of a variety of linear and heterocyclic scaffolds in place of the peptide backbone. Important chemical procedures and methods include the transient protection of charged peptides as neutral prodrugs for improved blood-brain penetration and the replacement of otherwise labile peptide bonds with heterocyclic rings, olefins and fluoroolefins, and ketomethylenes. Synthetic protocols towards the transition-state mimics and reactive "warheads," applicable in enzyme inhibitors, are also disclosed.

Peptidomimetics Protocols is the first book devoted to the practical synthetic preparation of peptide mimetics. Written by both academic and industrial synthetic organic and medicinal chemists, this book provides highly practical synthetic procedures for the generation of key peptide mimetics, and so immediately becomes a must-have desk reference and guide for all medicinal and pharmaceutical chemists engaged in the discovery and development of pharmaceuticals today.

Editors and affiliations

  • Wieslaw M. Kazmierski
    • 1
  1. 1.Glaxo Wellcome., Inc.Research Triangle Park

Bibliographic information

  • DOI https://doi.org/10.1385/0896035174
  • Copyright Information Humana Press 1999
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-0-89603-517-1
  • Online ISBN 978-1-59259-605-8
  • Series Print ISSN 1543-1894
  • Series Online ISSN 1940-6037
  • Buy this book on publisher's site
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