Abstract
As improvement in organ preservation has been obtained with hyperosmolar solutions, it has been deduced that inhibition of cellular swelling was beneficial, and that cellular swelling was one of the major pathways leading to cellular death. Disruption of cellular architecture and spatial separation of key enzymes are the suspected mechanisms. If this is the case, swelling in absence of anoxia should produce the same defects as anoxia. We have therefore attempted to produce similar swelling by flushing kidneys with hypotonic solutions or by submitting them to normothermic anoxia. The effects on glomerular function tested immediately or after 24 h were markedly different according to the origin of the oedema.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Fischer, J.H., Czerniak, A., Hauer, U. and Isselhard, W. (1978). A new simple method for optimal storage of ischemically damaged kidneys. Transplantation, 25, 43
Krebs, H. (1971). Report of a meeting: workshop on organ preservation. Surgery, 69, 321
Abouna, G.M., Lim, F., Cook, J.S., Grubb, W., Craig, S.S., Seibel, H.R. and Hume, D.M. (1972). Three-day canine kidney preservation. Surgery, 71, 436
Pontegnie-Istace, S. and Lambotte, L. (1977). Liver adenine nucleotide metabolism during hypothermic anoxia and a recovery period in perfusion. J. Surg. Res., 23, 339
Macknight, A.D.C. and Leaf, A. (1977). Regulation of cellular volume. Physiol. Rev 57, 510
Cohn, H. and Moses, M. (1966). The critical interval in cadaver kidney transplantation: function of canine renal autotransplants after variable periods of ischemia. Surgery, 60, 750
Grana, L., Donnellan, W.L. and Swenson, O. (1971). Low flow hypothermic renal perfusion. Surg. Gynecol. Obstet., 133, 401
Collins, G.M., Taft, P., Green, R.D., Ruprecht, R. and Halasz, N. A. (1977). Adenine nucleotide levels in preserved and ischemically injured canine kidneys. World J. Surg., 1, 237
Grundmann, R., Eichmann, J., Keckstein, J., Raab, M., Meusel, E. and Pichlmaier, H. (1977). Relationship between the prolongation of warm ischemia and the maximum available preservation period. Surgery, 81, 512
Grundmann, R., Bischoff, A., Albrod, A. and Pichlmaier, H. (1979). Canine kidney perfusion after various warm ischaemic periods. In Pegg, D. E. and Jacobsen, I. A. (eds.) Organ Preservation II, pp. 33–45. ( Edinburgh: Churchill Livingstone )
Collins, G. M., Bravo-Shugarman, M. and Terasaki, P. I. (1969). Kidney preservation for transportation. Initial perfusion and 30 hours′ ice storage. Lancet, 2, 1219
Downes, G., Hoffman, R., Huang, J. and Belzer, F.O. (1973). Mechanism of action of washout solutions for kidney preservation. Transplantation, 16, 46
Green, C.J. and Pegg, D.E. (1979). The effect of variation in electrolyte composition and osmolality of solutions for infusion and hypothermic storage of kidneys. In Pegg, D.E. and Jacobsen, I.A. (eds.) Organ Preservation II, pp. 86–100. ( Edinburgh: Churchill Livingstone )
Lambotte, L. and Wojcik, S. (1979). Ouabain inhibits the recovery of cellular volume in liver perfused with hypo-osmolar solution. Arch. Int. Phys. Bioch., 87, 335
Opelz, G. and Terasaki, P.I. (1976). Kidney preservation: perfusion versus cold storage - 1975. Transplant. Proc., 8, 121
Fischer, J. H., Miyata, M., Isselhard, W. and Casser, H. R. (1979). Hypotherme lagerung unter aeroben bedingungen. Einfluss unterschiedlicher freispiillosungen auf die function- serhaltung der niere. Langenbecks Arch. Chir., suppl., 307
Sterling, W.A., Datnow, B. and Diethelm, A.G. (1976). Sachs I solution and 7% mannitol solution for renal preservation. J. Surg. Res., 20, 103
Green, C.J. and Pegg, D.E. (1979). Mechanism of action of ‘intracellular’ renal preservation solutions. World J. Surg., 3, 115
Squifflet, J. P., Pirson, Y., Gianello, P., Van Cangh, P. and Alexandre, G.P.J. (1981). Safe preservation of human renal cadaver transplants by Euro-Collins’ solution up to 50 hours. Transplant. Proc., 13, 693
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 MTP Press Limited
About this chapter
Cite this chapter
Jamart, J., Lambotte, L. (1982). Renal function impairment in swelling with and without anoxia. In: Pegg, D.E., Jacobsen, I.A., Halasz, N.A. (eds) Organ Preservation. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6267-8_9
Download citation
DOI: https://doi.org/10.1007/978-94-011-6267-8_9
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-011-6269-2
Online ISBN: 978-94-011-6267-8
eBook Packages: Springer Book Archive