Organ Preservation

1. Front Matter

   Pages i-xxi

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2. Basic Reviews

   1. Front Matter

      Pages 1-1

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   2. Energetics and mitochondria

      • H. Feinberg

      Pages 3-15

   3. Membrane functions

      • M. J. Pringle

      Pages 17-25

   4. Biological significance and therapeutic potential of prostacyclin

      • S. Moncada, J. R. Vane

      Pages 27-32

   5. A free radical approach to tissue injury

      • H. H. Thaw, J. O. Forsberg, R. F. Del Maestro, B. Gerdin, F. N. McKenzie, K.-E. Arfors

      Pages 33-42

   6. Endothelial cell function and organ preservation ex vivo

      • J. D. Pearson, A. Hutchings, J. L. Gordon

      Pages 43-54

   7. The principles of organ storage procedures

      • D. E. Pegg

      Pages 55-66

3. Effects of Ischaemia and Anoxia

   1. Front Matter

      Pages 67-67

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   2. Recovery of renal function in the rat after warm ischaemia: functional and morphological changes

      • V. Marshall, P. Jablonski, B. Howden, E. Leslie, D. Rae, J. Tange

      Pages 69-76

   3. The dynamics of regional blood flow after ischaemic trauma of the rat kidney

      • L. Frödin, L. Karlberg, Ö. Källskog, B. J. Norlén, M. Wolgast

      Pages 77-81

   4. Renal function impairment in swelling with and without anoxia

      • J. Jamart, L. Lambotte

      Pages 83-89

   5. Prostacyclin and the ischaemic kidney

      • A. R. Mundy, J. M. Restorick, M. Bewick

      Pages 91-95

   6. Kidney blood flow and microcirculatory changes after autologous kidney transplantation

      • H. Wilms, E. Sinagowitz

      Pages 97-100

4. Biochemical and Pharmacological Aspects of Hypothermia

   1. Front Matter

      Pages 101-101

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   2. Future prospects in organ preservation

      • B. D. Ross

      Pages 103-108

   3. Tissue pH changes in renal preservation

      • P. Sehr, P. Bore, K. Thulborn, I. Papatheofanis, L. Chan, G. K. Radda

      Pages 109-112

   4. Study of human kidneys prior to transplantation by phosphorus nuclear magnetic resonance

      • L. Chan, M. E. French, D. G. Gadian, P. J. Morris, G. K. Radda, P. J. Bore et al.

      Pages 113-119

   5. Effects of hypothermia on anabolic and catabolic processes and on oxygen consumption in perfused rat livers

      • F. A. Zimmermann, H. G. Dietz, Ch. O. Köhler, N. Kilian, J. Kosterhon, R. Scholz

      Pages 121-126

   6. Mechanism of loss of mitochondrial functions during hypothermic storage of kidneys

      • J. H. Southard, R. M. Hoffmann, F. O. Belzer

      Pages 127-131

During the past 10 years, there have been many international meetings on the storage of organs prior to transplantation, and several have led to the publication of proceedings; there have also been a number of other books on this subject-. Most of these publications have concentrated on practical clinical aspects of organ preservation and on empirical animal experiments directed towards well-defined clinical objectives. Progress was rapid at first, but it is now generally agreed that there has been little improvement in techniques during the past 5 years, although understanding has certainly increased. In 1980 the Tissue Preservation and Banking Committee of the Transplantation Society decided that a fresh approach to the problem of improving preservation methods was needed: it was decided to hold a conference at which an opportunity would be provided to return to basic principles and to examine some of the advances that have occurred in recent yelns in areas of physiology that might be important for further improvements in preservation. The conference was held in Cambridge, UK, in April 1981 and this book is based upon the papers presented to that meeting and the work of a small discussion group that met after the main meeting. The book starts with six basic review chapters, followed by sections on the effects of ischaemia and anoxia, and on biochemical and pharmacological aspects of hypothermia. Chapters dealing with organ preservation by initial perfusion followed by hypothermia, and by continuous hypothermic perfusion, follow.

• assessment
• blood
• blood cell
• brain
• dopamine
• dynamics
• evaluation
• liver
• magnetic resonance
• nuclear magnetic resonance (NMR)
• pancreas
• physiology
• toxicity
• transplantation
• trauma

• MRC Medical Cryobiology Group, University Department of Surgery, Cambridge, UK

  D. E. Pegg

• Department of Nephrology, University Hospital, Odense C, Denmark

  I. A. Jacobsen

• Department of Surgery, University of California Medical Center, San Diego, USA

  N. A. Halasz

Policies and ethics