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Systems Biology: Towards Realistic and Useful Models of Molecular Networks

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Nuclear Receptors

Part of the book series: Proteins and Cell Regulation ((PROR,volume 8))

Abstract

Molecular biology is shifting focus from single molecules to networks of molecules. This development has changed our way of doing research and is challenging our thinking about cells. Cells turn out be complicated molecular systems displaying multivariate dynamics that can rarely be understood in terms of single molecules. One way to appreciate this complexity is to make mathematical models of signaling, gene, and metabolic network to assess the systemic consequences of specific molecular perturbations. This chapter gives a brief overview of some of the approach in mathematical modeling of molecular networks. We choose to keep the mathematical detail minimal and highlight a number of concepts and approaches that are emerging in the analysis of molecular networks.

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Notes

  1. 1.

    from \(1/(k^ + \cdot X \cdot Y)\) with k + as 10–3 pM–1 min–1 and X and Y equal to 0.8 pM

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Author information

Authors and Affiliations

  1. Regulatory Networks Group, Netherlands Institute for Systems Biology, University of Amsterdam, Amsterdam, The Netherlands

    F.J. Bruggeman

  2. Life Sciences, Institute for Mathematics and Computer Science (CWI), Amsterdam, 1098, SJ, The Netherlands

    F.J. Bruggeman

  3. Molecular Cell Physiology, Vrije Universiteit, Amsterdam, 1081, HV, The Netherlands

    F.J. Bruggeman, A. Kolodkin, K. Rybakova, M. MonÉ & H.V. Westerhoff

  4. Manchester Centre for Integrative Systems Biology, Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, UK

    H.V. Westerhoff

Authors
  1. F.J. Bruggeman
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  2. A. Kolodkin
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  3. K. Rybakova
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  4. M. MonÉ
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  5. H.V. Westerhoff
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Editor information

Editors and Affiliations

  1. School of Biosciences, University of Birmingham, Birmingham, B15 2TT, United Kingdom

    Chris M. Bunce

  2. Dept. Pharmacology & Therapeutics, Roswell Park Cancer Institute, Elm & Carlton Streets, Buffalo, 14263, U.S.A.

    Moray J. Campbell

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Bruggeman, F., Kolodkin, A., Rybakova, K., MonÉ, M., Westerhoff, H. (2010). Systems Biology: Towards Realistic and Useful Models of Molecular Networks. In: Bunce, C., Campbell, M. (eds) Nuclear Receptors. Proteins and Cell Regulation, vol 8. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3303-1_18

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