Nuclear Receptors

Current Concepts and Future Challenges

  • Chris M. Bunce
  • Moray J. Campbell

Part of the Proteins and Cell Regulation book series (PROR, volume 8)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Chris M. Bunce, Moray J. Campbell
    Pages 1-13
  3. Gabriel Markov, FranÇois Bonneton, Vincent Laudet
    Pages 15-29
  4. Robert H. Oakley, John A. Cidlowski
    Pages 63-89
  5. Stefan Nilsson, Jan-Åke Gustafsson
    Pages 91-141
  6. James T. Dalton, Wenqing Gao
    Pages 143-182
  7. BjÖRn VennstrÖM, Hong Liu, Douglas Forrest
    Pages 183-201
  8. Orla Maguire, Moray J. Campbell
    Pages 203-236
  9. Audrey Cras, Fabien Guidez, Christine Chomienne
    Pages 237-258
  10. Linda M. Sanderson, Sander Kersten
    Pages 259-285
  11. Curtis Klaassen, Hong Lu
    Pages 287-305
  12. Fxr
    Yandong Wang, Weidong Chen, Xiaosong Chen, Wendong Huang
    Pages 307-326
  13. Su Liu, Shaozhen Xie, Yi-fen Lee, Chawnshang Chang
    Pages 327-343
  14. Antimo Migliaccio, Gabriella Castoria, Ferdinando Auricchio
    Pages 365-379
  15. Martin Hewison
    Pages 381-417
  16. F.J. Bruggeman, A. Kolodkin, K. Rybakova, M. MonÉ, H.V. Westerhoff
    Pages 439-453
  17. Back Matter
    Pages 455-457

About this book


In 1890 a case of myxedema was treated in Lisbon by the implantation of a sheep thyroid gland with the immediate improvement in the patient’s condition. A few years later, medications for the then ill-explained condition of the menopause included tablets made from cow ovaries. In the first quarter of the 20th century the identification of vitamin D, and its sunlight driven production in skin, paved the way to the elimination of rickets as a major medical problem. Twenty years or so later, Sir Vincent Wigglesworth established the endocrine basis of developmental moulting in insects, arguably the most commonly performed animal behaviour on Planet Earth. A paradigm that would unify these disparate observations arose between 1985 and 1987 beginning with the identification of the glucocorticoid receptor and the nuclear receptor super-family. What follows is a timely and positive manifestation of the capacity, productivity and value of international human scientific endeavour. Based on intrigue, lively competition and cooperation a global effort has rapidly fostered a school of biology with widespread ramifications for the understanding of metazoan animals, the human condition and the state of the planet. This book is the first this century to try and capture the spirit of this endeavour, to depict where the field is now and to identify some of the challenges and opportunities for the future.


ATP Metazoa Vitamin D development estrogen receptor glucocorticoid hormone receptors metabolism nuclear receptors regulation thyroid hormone

Editors and affiliations

  • Chris M. Bunce
    • 1
  • Moray J. Campbell
    • 2
  1. 1.School of BiosciencesUniversity of BirminghamBirminghamUnited Kingdom
  2. 2.Dept. Pharmacology & TherapeuticsRoswell Park Cancer InstituteBuffaloU.S.A.

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