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Virus-Neuron-Cytotoxic T Lymphocyte Interactions

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HIV and Dementia

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 202))

Abstract

Neurons have evolved unique strategies to evade immune recognition which allow viruses to infect and persist, yet resist attack by antiviral cytotoxic T lymphocytes (CTLs). However, the ability of activated CTLs to percolate through the normal central nervous system (CNS) (Hickey et al. 1991), coupled with focal upregulation of immune regulatory proteins on resident CNS cells in response to CNS insults (Canella et al. 1990), has suggested that the immune response can serve either in the resolution of viral infections of the CNS or in the precipitation of CNS disease.

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Author information

Author notes

  1. G. F. Rall

    Present address: The Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA, 19111, USA

Authors and Affiliations

  1. Department of Neuropharmacology, Division of Virology, The Scripps Research Institute, 10666 North Torrey Pines Road, Mail Drop IMM-6, La Jolla, CA, 92037, USA

    G. F. Rall & M. B. A. Oldstone

Authors
  1. G. F. Rall
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  2. M. B. A. Oldstone
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Editor information

Editors and Affiliations

  1. Department of Neuropharmacology, Division of Virology, The Scripps Research Institute, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA

    Michael B. A. Oldstone

  2. Molecular and Cellular Neuroscience Research Branch, Division of Neuroscience and Behavioral Science, National Institutes of Health, National Institute of Mental Health, 5600 Fishers Lane, Rm 11C-06, 20857, Rockville, MD, USA

    Ljubiša Vitković (Chief, Neuroimmunology/Neurovirology Program) (Chief, Neuroimmunology/Neurovirology Program)

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© 1995 Springer-Verlag Berlin Heidelberg

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Rall, G.F., Oldstone, M.B.A. (1995). Virus-Neuron-Cytotoxic T Lymphocyte Interactions. In: Oldstone, M.B.A., Vitković, L. (eds) HIV and Dementia. Current Topics in Microbiology and Immunology, vol 202. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79657-9_17

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  • DOI: https://doi.org/10.1007/978-3-642-79657-9_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79659-3

  • Online ISBN: 978-3-642-79657-9

  • eBook Packages: Springer Book Archive

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