Abstract
Cytotoxic T cells that recognize dengue fever viral (DFV) peptides were reported. To predict the cleavage pattern of DFV proteins by cytoplasmic proteasomes into nonapeptides with motifs fitting known HLA class I molecules, the computer program “Findpatterns” was used. In this study the combined amino acid motifs for proteolytic cleavages and the HLA class I haplotype-restricted peptides were analyzed. It was noted that putative peptides with motifs of HLA A2 and A68 were abundant compared with nonapeptides with motifs HLA A24, B8, B35, and B53. The possible interpretation of the computer analysis in explaining the cellular immune response in endogenous populations of endemic DF is discussed.
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References
Porterfield J.S., Adv Virus Res31 335–355, 1986.
Halstead S.B., Science239 476–481, 1988.
Halstead S.B., Bull World Health Org58 1–21, 1990.
Becker Y., Virus Genes9 33–45, 1994.
Walker C., Selby M., Erickson A., Do D.C., Valensi J-P., and Van Nest G., Proc Natl Acad Sci USA89 7915–7918, 1992.
Becker Y., Virus Genes in press 1995.
Bukowsky J.F., Kurane I., Lai C-J., Bray M., Falgout B., and Ennis F.A., J Virol63 5086–5091, 1989.
Hill A.B., Müllbacher A., Parrish C., Coia G., Westaway E.G., and Blanden R.V., J Gen Virol73 1115–1123, 1992.
Kast W.M., Roux L., Curren J., Blom H.J.J., Voordouw A.C., Meloen R.H., Kolakofsky D., and Melief C.J.M., Proc Natl Acad Sci USA88 2283–2287, 1991.
Chiewsilp P., McNair Scott R., and Bhamarapravati N., Am J Med Hyg30 1100–1105, 1981.
Devereaux J., Haberlin P., and Smithies O., Nucleic Acids Res12 387–395, 1984.
Bond J.S. and Butler P.E., Annu Rev Biochem56 333–364, 1987.
Becker Y., Virus Genes8 249–270, 1994.
Wei M.L. and Cresswell P., Nature356 443–446, 1993.
Falk K., Rotzschke O., Stevanovic S., Jung G., and Rammensee H.-G., Nature351 290–296, 1991.
Hunt D.F., Henderson R.A., Shabanowitz J., Skaguchi K., Michel H., Sevilik N., Cox A., and Engelhard, Science255 1261–1263, 1992.
Guo H.-C., Jardetsky T.S., Garrett R.P.J., Lane W.S., Strominger J.L., and Wiley D.C., Nature360 364–366, 1992.
Casanova T.L., Martinon F., Gournier H., Barra C., Pannetier C., Regnault A., Kouritsky P., Cerottini J.-C., and Maryanski J.L., J Exp Med177 811–820, 1993.
Jardetsky T.S., Lane W., Robinson R., Madden D., and Wiley D.C., Nature353 326–329, 1991.
Parker K.C., Dibrino M., Hull L., and Coligan J.F., J Immunol149 1896–1904, 1992.
Madden D.R., Gorga J.C., Strominger L.L., and Wiley D.C., Nature353 321–325, 1991.
Madden D.R., Gorga J.C., Strominger L.L., and Wiley D.C., Cell70 1035–1048, 1992.
Madden D.R., Garboczi D.N., and Wiley D.C., Cell75 693–708, 1993.
Townsend A., and Bodmer H., Annu Rev Immunol7 601–624, 1989.
Scorza-Smeraldi R., Fabio A., Lazzarin A., Eisera N., Warti Foppa C., Moroni M., and Zanussi C., Hum Immunol22 73–79, 1987.
Kaslow R.A., Duquesnoy R., Van Raden M., Kingsley L., Marrari L.C., Friedman H., Su S., Saah A.J., Detels R., Phair J., and Rinaldo C., Lancet335 927–930, 1990.
Wolf H., Modrow S., Motz M., Jameson B., Hermann G., and Fortsch B, CABIOS4 187–191, 1988.
Chou P.Y. and Fasman G.D., Ann Rev Biochem47 251–276, 1978.
Garnier J., Osguthorpe D.J., and Robson B., J Mol Biol120 97–120, 1978.
Fu J., Tan B.H., Yap E.H., Chan Y.C., Tan Y.H., Virol.188 953–958, 1992.
Coia G., Parker M.D., Speight G., Byrne M.E., and Westaway E.G., J Gen Virol69 1–21, 1988.
Chu M.C., O'Rourke E.J., and Trent D.W., J Gen Virol70 1701–1712, 1989.
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Becker, Y. Computer simulations to predict the availability of peptides with known HLA class I motifs generated by proteolysis of dengue fever virus (DFV) type 1 structural and nonstructural proteins in infected cells. Virus Genes 10, 195–203 (1995). https://doi.org/10.1007/BF01701808
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DOI: https://doi.org/10.1007/BF01701808