Abstract
Of major concern in N-of-1 trials, common to any epidemiological approach, is the introduction of bias and confounding. These factors may modify the size of the treatment estimate or shift the treatment estimate away from its true value. The methodological approaches of randomization, allocation concealment, and blinding are employed to prevent or minimize confounding and bias in trials. This chapter provides definitions and describes the various methods of randomization, allocation concealment, and blinding that can be adopted in N-of-1 trials. In addition, the chapter details the roles of specific research staff and the information required for the reporting of N-of-1 trial blinding methods in medical journals.
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Senior, H. (2015). Randomization, Allocation Concealment, and Blinding. In: Nikles, J., Mitchell, G. (eds) The Essential Guide to N-of-1 Trials in Health. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-7200-6_7
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DOI: https://doi.org/10.1007/978-94-017-7200-6_7
Publisher Name: Springer, Dordrecht
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