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Meta-analysis, Review and Update of Methodologies

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Statistics Applied to Clinical Studies

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Abstract

In 1982 thrombolytic therapy for acute coronary syndromes was controversial. In a meta-analysis of seven trials Stampfer et al. found a reduced risk of mortality of 0.80 (95% confidence interval 0.68–0.95). These findings (Stampfer et al. 1982) were not accepted by cardiologists until 1986, when a large clinical trial confirmed the conclusions (Gruppo Italiano per lo Studio della Streptochinasi nell’Infarto Miocardico (GISSI) 1986), and streptokinase became widely applied.

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Authors and Affiliations

  1. Applied to Clinical Trials, European Interuniversity College of Pharmaceutical Medicine, Lyon, France

    Ton J. Cleophas (Past-President American College of Angiology Co-Chair Module Statistics) & Aeilko H. Zwinderman (President-Elect International Society of Biostatistics Co-Chair Module Statistics)

  2. Department of Medicine, Albert Schweitzer Hospital, Dordrecht, Netherlands

    Ton J. Cleophas (Past-President American College of Angiology Co-Chair Module Statistics)

  3. Department of Biostatistics and Epidemiology, Academic Medical Center, Amsterdam, Netherlands

    Aeilko H. Zwinderman (President-Elect International Society of Biostatistics Co-Chair Module Statistics)

Authors
  1. Ton J. Cleophas
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  2. Aeilko H. Zwinderman
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Cleophas, T.J., Zwinderman, A.H. (2012). Meta-analysis, Review and Update of Methodologies. In: Statistics Applied to Clinical Studies. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2863-9_33

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