Statistics Applied to Clinical Studies

  • Ton J. Cleophas
  • Aeilko H. Zwinderman

Table of contents

  1. Front Matter
    Pages i-xxxv
  2. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 1-14
  3. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 15-39
  4. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 41-60
  5. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 61-68
  6. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 69-75
  7. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 77-93
  8. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 95-101
  9. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 103-108
  10. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 109-117
  11. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 119-131
  12. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 133-138
  13. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 149-159
  14. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 161-176
  15. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 187-197
  16. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 199-218
  17. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 219-225
  18. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 227-231

About this book

Introduction

Thanks to the omnipresent computer, current statistics can include data files of many thousands of values, and can perform any exploratory analysis in less than seconds. This development, however fascinating, generally does not lead to simple results. We should not forget that clinical studies are, mostly, for confirming prior hypotheses based on sound arguments, and the simplest tests provide the best power and are adequate for such studies. In the past few years the authors of this 5th edition, as teachers and research supervisors in academic and top-clinical facilities, have been able to closely observe the latest developments in the field of clinical data analysis, and they have been able to assess their performance. In this 5th edition the 47 chapters of the previous edition have been maintained and upgraded according to the current state of the art, and 20 novel chapters have been added after strict selection of the most valuable and promising novel methods. The novel methods are explained using practical examples and step-by-step analyses readily accessible for non-mathematicians. All of the novel chapters have been internationally published by the authors in peer-reviewed journal, including the American Journal of Therapeutics, the European Journal of Clinical Investigation, The International journal of Clinical Pharmacology and therapeutics, and other journals, and permission is granted by all of them to use this material in the current book. We should add that the authors are well-qualified in their fields of knowledge. Professor Zwinderman is president-elect of the International Society of Biostatistics, and Professor Cleophas is past-president of the American College of Angiology. From their expertise they should be able to make adequate selections of modern methods for clinical data analysis for the benefit of physicians, students, and investigators. The authors, although from a different discipline, one clinician and one statistician, have been working and publishing together for over 10 years, and their research of statistical methodology can be characterized as a continued effort to demonstrate that statistics is not mathematics but rather a discipline at the interface of biology and mathematics. They firmly believe that any reader can benefit from this clinical approach to statistical data analysis.

Keywords

clinical research clinical trials evidence based medicine pharmaceutical medicine statistics

Authors and affiliations

  • Ton J. Cleophas
    • 1
  • Aeilko H. Zwinderman
    • 2
  1. 1., Department MedicineAlbert Schweitzer HospitalDordrechtNetherlands
  2. 2., Dept. Epidemiology and BiostatisticsAcademic Medical CenterAmsterdamNetherlands

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-007-2863-9
  • Copyright Information Springer Science+Business Media B.V. 2012
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-94-007-2862-2
  • Online ISBN 978-94-007-2863-9
  • About this book

Industry Sectors