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Autoimmunity: Aging Mouse Model for Autoimmune Diseases

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Handbook of Immunosenescence

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Abstract

Recent evidences suggest that the apoptotic pathway plays a central role in tolerazing T cells to tissue-specific self-antigen and may drive the age-related autoimmune phenomenon. Primary Sjögren’s syndrome (SS) is an autoimmune disorder characterized by lymphocytic infiltrates and destruction of the exocrine glands and systemic production of autoantibodies to the ribonucleoprotein (RNP) particles SS-A/Ro and SS-B/La. We found that aging-associated disturbances in T cell homeostasis are accelerated in the animal model with SS, resulting in the development of extraglandular manifestation including autoimmune arthritis and interstitial pneumonia. We demonstrated that tissue-specific apoptosis may contribute to autoantigen cleavage, leading to the age-related acceleration of autoimmune exocrinopathy. The immune system undergoes profound changes with advancing age that are beginning to be understood and that need to be incorporated into the pathogenesis of SS. The studies reviewed the molecular mechanisms on aging-associated progression and acceleration in animal model of autoimmune exocrinopathy.

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Authors and Affiliations

  1. Department of Oral Molecular Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan

    Yoshio Hayashi & Naozumi Ishimaru

Authors
  1. Yoshio Hayashi
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  2. Naozumi Ishimaru
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Corresponding author

Correspondence to Yoshio Hayashi .

Editor information

Editors and Affiliations

  1. Division of Geriatrics Research Center on Aging, University of Sherbrooke Dept. of Medicine, Sherbrooke, Québec, Canada

    Tamas Fulop

  2. Dept of Experimental Pathology, University of Bologna, Bologna, Italy

    Claudio Franceschi

  3. Institute for Health and Life Sciences, Tokyo, Japan

    Katsuiku Hirokawa

  4. Center for Medical Research, University of Tübingen, Tübingen, Germany

    Graham Pawelec

Section Editor information

  1. Research Center on Aging, Department of Medicine, Immunology Graduate Programme, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada

    Tamas Fulop

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Hayashi, Y., Ishimaru, N. (2018). Autoimmunity: Aging Mouse Model for Autoimmune Diseases. In: Fulop, T., Franceschi, C., Hirokawa, K., Pawelec, G. (eds) Handbook of Immunosenescence. Springer, Cham. https://doi.org/10.1007/978-3-319-64597-1_52-1

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  • DOI: https://doi.org/10.1007/978-3-319-64597-1_52-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-64597-1

  • Online ISBN: 978-3-319-64597-1

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