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Aging and Malignant Hemopathies: A Complex Multistep Process

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Handbook of Immunosenescence

Abstract

The probability of developing cancer, primarily malignant hemopathies, increases with age. This complex relationship between cancer and aging has been extensively studied; cellular senescence, a protective mechanism in response to DNA damage, can induce permanent growth arrest and resistance to apoptosis. Chronological age also favors the accumulation of genetic and epigenetic changes that are important contributing factors in the complex pathogenesis of cancer. Other age-related mechanisms such as impairment of cancer prevention and clonal restriction of hematopoietic stem cells also lead to the development of cancer. However, a full understanding of the process of aging is far from complete with many open questions currently under investigation. This review will focus on the complex multistep interplay between aging and a higher incidence of malignant hemopathies.

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Authors and Affiliations

  1. Clinical and Experimental Hematology, Institut Jules Bordet, ULB, Brussels, Belgium

    Vu Luan Dang Chi & Dominique Bron

  2. Molecular Immunology Unit, Institut Jules Bordet, ULB, Brussels, Belgium

    Vu Luan Dang Chi & Karen Willard-Gallo

  3. Anatomo-pathology Department, Institut Jules Bordet, ULB, Brussels, Belgium

    Catherine Sibille

  4. Department of Hematology, Institut Jules Bordet, ULB, Brussels, Belgium

    Vu Luan Dang Chi & Dominique Bron

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  1. Vu Luan Dang Chi
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  2. Catherine Sibille
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  3. Karen Willard-Gallo
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  4. Dominique Bron
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Correspondence to Vu Luan Dang Chi .

Editor information

Editors and Affiliations

  1. Division of Geriatrics Research Center on Aging, University of Sherbrooke Dept. of Medicine, Sherbrooke, Québec, Canada

    Tamas Fulop

  2. Dept of Experimental Pathology, University of Bologna, Bologna, Italy

    Claudio Franceschi

  3. Institute for Health and Life Sciences, Tokyo, Japan

    Katsuiku Hirokawa

  4. Center for Medical Research, University of Tübingen, Tübingen, Germany

    Graham Pawelec

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Dang Chi, V.L., Sibille, C., Willard-Gallo, K., Bron, D. (2018). Aging and Malignant Hemopathies: A Complex Multistep Process. In: Fulop, T., Franceschi, C., Hirokawa, K., Pawelec, G. (eds) Handbook of Immunosenescence. Springer, Cham. https://doi.org/10.1007/978-3-319-64597-1_142-1

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  • DOI: https://doi.org/10.1007/978-3-319-64597-1_142-1

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  • Print ISBN: 978-3-319-64597-1

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