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Circulating Mitochondrial DNA as a Potential Biomarker for Aging and its Related Complications

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Handbook of Immunosenescence

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Abstract

Mitochondria are organelles present in all nucleated cells that provide energy, in the form of ATP. They are supposed to originate from symbiotic bacteria, and thus their components, including mitochondrial DNA (mtDNA) and formylated proteins, when released extracellularly, can act as molecules that contain motifs defined as “damage-associated molecular patterns” (DAMPs) that can activate the innate immune system and in turn trigger or sustain inflammation. A growing body of evidence reveals that mitochondrial DAMPs can play a main role in the low-grade, chronic inflammatory status that characterize elderly people, as well as in some age-associated comorbidities.

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Authors and Affiliations

  1. Department of Surgery, Medicine, Dentistry and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy

    Elena Bianchini & Milena Nasi

  2. Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy

    Marcello Pinti, Sara De Biasi & Anna De Gaetano

  3. Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, Italy

    Lara Gibellini & Andrea Cossarizza

  4. Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy

    Simone Pecorini

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  1. Lara Gibellini
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Correspondence to Andrea Cossarizza .

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Editors and Affiliations

  1. Division of Geriatrics Research Center on Aging, University of Sherbrooke Dept. of Medicine, Sherbrooke, Québec, Canada

    Tamas Fulop

  2. Dept of Experimental Pathology, University of Bologna, Bologna, Italy

    Claudio Franceschi

  3. Institute for Health and Life Sciences, Tokyo, Japan

    Katsuiku Hirokawa

  4. Center for Medical Research, University of Tübingen, Tübingen, Germany

    Graham Pawelec

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Gibellini, L. et al. (2018). Circulating Mitochondrial DNA as a Potential Biomarker for Aging and its Related Complications. In: Fulop, T., Franceschi, C., Hirokawa, K., Pawelec, G. (eds) Handbook of Immunosenescence. Springer, Cham. https://doi.org/10.1007/978-3-319-64597-1_122-1

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  • DOI: https://doi.org/10.1007/978-3-319-64597-1_122-1

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  • Print ISBN: 978-3-319-64597-1

  • Online ISBN: 978-3-319-64597-1

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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