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Predictive Assessment of Biological Damage Due to Ion Beams

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Book cover Nanoscale Insights into Ion-Beam Cancer Therapy

Abstract

This chapter presents recent achievements in validation of the Multiscale Approach (MSA) to the physics of radiation damage with ions. An analytical recipe for the assessment of biological damage, developed using the phenomenon-based MSA, has been applied to numerous experiments, where survival curves were obtained for different cells and irradiation conditions. Contrary to other, in essence empirical methods for evaluation of macroscopic effects of ionizing radiation, the MSA predicts the biodamage based on the physical effects related to ionization of the medium, transport of secondary particles, chemical interactions, thermo-mechanical pathways of biodamage, and heuristic biological criteria for cell survival. An extensive comparison with experimental data for cell survival probability demonstrates the validity of the MSA to predict the macroscopic effects of ionizing radiation through an understanding of biological damage on the nanoscale. The analysis performed allows us to conclude that the biodamage can be accurately predicted in both aerobic and hypoxic conditions. Therefore, we anticipate this method to give great impetus to the practical improvement of ion-beam cancer therapy and the development of more efficient treatment protocols.

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Acknowledgements

We acknowledge the financial support received from the European Union Seventh Framework Programme (PEOPLE-2013-ITN-ARGENT project) under grant agreement no. 608163.

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Authors and Affiliations

  1. Instituto de Fisica Fundamental, Consejo Superior de Investigaciones Cientificas (CSIC), Serrano 113-bis, 28006, Madrid, Spain

    Alexey Verkhovtsev

  2. MBN Research Center, 60438, Frankfurt am Main, Germany

    Alexey Verkhovtsev & Eugene Surdutovich

  3. MBN Research Center at Frankfurter Innovationszentrum Biotechnologie, Altenhöferallee 3, 60438, Frankfurt am Main, Germany

    Andrey V. Solov’yov

  4. A.F. Ioffe Physical-Technical Institute, Polytekhnicheskaya Ul. 26, 194021, Saint Petersburg, Russia

    Andrey V. Solov’yov

  5. Department of Physics, Oakland University, Rochester, MI, 48309, USA

    Eugene Surdutovich

Authors
  1. Alexey Verkhovtsev
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  2. Eugene Surdutovich
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  3. Andrey V. Solov’yov
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Correspondence to Alexey Verkhovtsev .

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Editors and Affiliations

  1. Frankfurter Innovationszentrum Biotechnologie, MBN Research Center , Frankfurt, Germany

    Andrey V. Solov’yov

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Verkhovtsev, A., Surdutovich, E., Solov’yov, A.V. (2017). Predictive Assessment of Biological Damage Due to Ion Beams. In: Solov’yov, A. (eds) Nanoscale Insights into Ion-Beam Cancer Therapy. Springer, Cham. https://doi.org/10.1007/978-3-319-43030-0_11

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