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Type I Interferons in Immune Defense Against Streptococci

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Bacterial Activation of Type I Interferons

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Summary

Infections with Streptococcus pneumoniae, Group A Streptococcus (GAS), and Group B Streptococcus (GBS) are among the most frequent bacterial infections in humans and major causes of diseases. Immune responses against streptococci include the induction of type I interferons (IFNs), which are immunomodulatory cytokines with well-established antiviral functions, but ambiguous roles in bacterial infections. Studies of streptococcal infections further highlight the importance of type I IFN signaling in host defense against bacterial pathogens. We discuss the complexity of type I IFN induction by streptococcal ligands and their engagement in stimulating innate immune receptors. Furthermore, we elaborate on the broad physiological role and different impacts of type I IFN signaling on the outcome of streptococcal infections and influenza virus coinfections.

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Authors and Affiliations

  1. Max F. Perutz Laboratories, University of Vienna, Dr. Bohr-Gasse 9, 1030, Vienna, Austria

    Pavel Kovarik, Virginia Castiglia & Marton Janos

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  1. Pavel Kovarik
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  2. Virginia Castiglia
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Correspondence to Pavel Kovarik .

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  1. Columbia University, New York, New York, USA

    Dane Parker

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Kovarik, P., Castiglia, V., Janos, M. (2014). Type I Interferons in Immune Defense Against Streptococci. In: Parker, D. (eds) Bacterial Activation of Type I Interferons. Springer, Cham. https://doi.org/10.1007/978-3-319-09498-4_4

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