Bacterial Activation of Type I Interferons

  • Dane┬áParker

Table of contents

  1. Front Matter
    Pages i-vii
  2. Pavel Kovarik, Virginia Castiglia, Marton Janos
    Pages 43-59
  3. Miqdad O. Dhariwala, Deborah M. Anderson
    Pages 87-96
  4. Sebastian A. Stifter, Mikaela C. Coleman, Carl G. Feng
    Pages 109-124
  5. Back Matter
    Pages 125-129

About this book


The type I interferon (IFN) signaling pathway is well recognized as a pathway activated by viral infections. It is activated by a variety of microbial pattern recognition receptors including the Toll-like receptors, NOD-like receptors and several cytosolic receptors. Activation of the type I IFN pathway leads to the production of both antiviral factors and products that influence immune cell function. More recently it has been shown that bacteria are also capable of activating this pathway.

Bacterial Activation of Type I Interferons reviews both the current understanding of how different bacterial species are able to activate this pathway as well as the influence type I IFNs have on the outcome to infection. Several different bacterial species are covered, spanning Gram positive and Gram negative, intracellular, extracellular, and different host infection sites. An introduction to the pathogenesis of each organism is provided, and the signaling molecules involved in the activation of the type I IFN pathway and the role it plays in animal infection models are also covered.


Bacterial Pathogenesis Interferon Beta Pathogens Type I Interferons innate immunity

Editors and affiliations

  • Dane┬áParker
    • 1
  1. 1.Columbia UniversityNew YorkUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2014
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-09497-7
  • Online ISBN 978-3-319-09498-4
  • About this book
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