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Induction and Consequences of the Type I IFN Response to Listeria monocytogenes

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Bacterial Activation of Type I Interferons

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Summary

Listeria monocytogenes is a Gram-positive intracellular bacterial pathogen. During infection of host cells, L. monocytogenes introduces microbial components into both vacuolar compartments and the cytoplasm. Innate receptors in these compartments recognize the pathogen and induce pro-inflammatory cytokines, including type I interferons (IFNs). Strikingly, production of type I IFNs and responsiveness to these cytokines is deleterious to the host during infections by L. monocytogenes and several other bacteria. Hence, a better understanding of their regulation has potential importance for antimicrobial therapy. Recent studies have revealed involvement of cytosolic immune sensors and pathways in host detection of L. monocytogenes components and stimulation of type I IFN production. This chapter will examine these receptors and their downstream adaptor and effector molecules that have proven to be vital for signal transduction and subsequent type I IFN secretion.

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Authors and Affiliations

  1. Integrated Department of Immunology, University of Colorado School of Medicine, Aurora, CO, 80045, USA

    Emily M. Eshleman & Laurel L. Lenz

  2. Integrated Department of Immunology, National Jewish Health, Denver, CO, 80206, USA

    Laurel L. Lenz

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  1. Emily M. Eshleman
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  2. Laurel L. Lenz
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Correspondence to Laurel L. Lenz .

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  1. Columbia University, New York, New York, USA

    Dane Parker

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Eshleman, E.M., Lenz, L.L. (2014). Induction and Consequences of the Type I IFN Response to Listeria monocytogenes . In: Parker, D. (eds) Bacterial Activation of Type I Interferons. Springer, Cham. https://doi.org/10.1007/978-3-319-09498-4_2

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