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A Method to Investigate Astrocyte and Microglial Morphological Changes in the Aging Brain of the Rhesus Macaque

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Astrocytes

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1938))

Abstract

With a rapidly aging population, studies of neuroinflammation and degeneration associated with eugeric aging are becoming critical. Using the unique archive at the Tulane National Primate Research Center as a resource, we have developed tools to quantify morphological changes in astrocytes and microglia across the life span of monkeys. This method can be used for morphometric studies of multiple parameters simultaneously in an unbiased manner.

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Author information

Author notes

  1. Kim M. Lee

    Present address: Tulane National Primate Research Center, Covington, LA, USA

Authors and Affiliations

  1. Tulane National Primate Research Center, Covington, LA, USA

    Kevin B. Chiu, Katelyn N. Robillard & Andrew G. MacLean

  2. Department of Biomedical Engineering, Tulane University, New Orleans, LA, USA

    Kevin B. Chiu

  3. Vanderbilt Hospital Nashville, Nashville, TN, USA

    Kim M. Lee

  4. Tulane Program in Biomedical Sciences, Tulane University School of Medicine, New Orleans, LA, USA

    Kim M. Lee & Andrew G. MacLean

  5. Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA, USA

    Katelyn N. Robillard

  6. Tulane Brain Institute, Tulane University, New Orleans, LA, USA

    Andrew G. MacLean

  7. Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA

    Andrew G. MacLean

Authors
  1. Kevin B. Chiu
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  2. Kim M. Lee
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  3. Katelyn N. Robillard
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  4. Andrew G. MacLean
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Corresponding author

Correspondence to Andrew G. MacLean .

Editor information

Editors and Affiliations

  1. Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany

    Barbara Di Benedetto

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Chiu, K.B., Lee, K.M., Robillard, K.N., MacLean, A.G. (2019). A Method to Investigate Astrocyte and Microglial Morphological Changes in the Aging Brain of the Rhesus Macaque. In: Di Benedetto, B. (eds) Astrocytes. Methods in Molecular Biology, vol 1938. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-9068-9_19

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  • DOI: https://doi.org/10.1007/978-1-4939-9068-9_19

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-9067-2

  • Online ISBN: 978-1-4939-9068-9

  • eBook Packages: Springer Protocols

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