Abstract
Aggregation of tau protein is a pathological hallmark of Alzheimer’s disease and other neurodegenerative tauopathies. Inhibition of tau aggregation could provide a method for the treatment of these disorders. Methods to identify tau aggregation inhibitors (TAIs) in vitro are useful and here we describe assays for TAIs using purified recombinant tau protein fragments in a cell-free immunoassay format and a stably transfected cell model to create a more physiological environment.
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Rickard, J.E., Horsley, D., Wischik, C.M., Harrington, C.R. (2017). Assays for the Screening and Characterization of Tau Aggregation Inhibitors. In: Smet-Nocca, C. (eds) Tau Protein. Methods in Molecular Biology, vol 1523. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6598-4_8
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DOI: https://doi.org/10.1007/978-1-4939-6598-4_8
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