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Kynurenine 3-monooxygenase

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Class 1 Oxidoreductases XI

Part of the book series: Springer Handbook of Enzymes ((HDBKENZYMES,volume 26))

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References

  1. Okamoto, H.; Hayaishi, O.: Flavin adenine dinucleotide requirement for kynurenine hydroxylase of rat liver mitochondria. Biochem. Biophys. Res. Commun., 29, 394–399 (1967)

    Article  PubMed  CAS  Google Scholar 

  2. Saito, Y.; Hayaishi, O.; Rothenberg, S.: Studies on oxygenases: Enzymatic formation of 3-hydroxy-l-kynurenine from l-kynurenine. J. Biol. Chem., 229, 921–934 (1957)

    PubMed  CAS  Google Scholar 

  3. Nisimoto, Y.; Takeuchi, F.; Shibata, Y.: Molecular properties of l-kynurenine 3-hydroxylase from rat liver mitochondria. J. Biochem., 81, 1413–1425 (1977)

    PubMed  CAS  Google Scholar 

  4. Nisimoto, Y.; Takeuchi, F.; Shibata, Y.: Isolation of l-kynurenine 3-hydroxylase from the mitochondrial outer membrane of rat liver. J. Biochem., 78, 573–581 (1975)

    PubMed  CAS  Google Scholar 

  5. Nishimoto, Y.; Takeuchi, F.; Shibata, Y.: Purification of l-kynurenine 3-hydroxylase by affinity chromatography. J. Chromatogr., 169, 357–364 (1979)

    Article  PubMed  CAS  Google Scholar 

  6. McLean-Bowen, C.A.; Parks, L.W.: Corresponding changes in kynurenine hydroxylase activity, membrane fluidity, and sterol composition in Saccharomyces cerevisiae mitochondria. J. Bacteriol., 143, 1325–1333 (1981)

    Google Scholar 

  7. Schott, H.H.; Staudinger, H.: The regulatory function of l-kynurenine 3-hydroxylase (EC 1.14.1.2) for the biosynthesis of pyridine nucleotides in anaerobically and aerobically grown Saccharomyces cerevisiae. Hoppe-Seyler’s Z. Physiol. Chem., 352, 1654–1658 (1971)

    PubMed  CAS  Google Scholar 

  8. Saito, K.; Quearry, B.J.; Saito, M.; Nowak, T.S. Jr.; Markey S.P.; Heyes, M.P.: Kynurenine 3-hydroxylase in brain: species activity differences and effect of gerbil cerebral ischemia. Arch. Biochem. Biophys., 307, 104–109 (1993)

    Article  PubMed  CAS  Google Scholar 

  9. Pinamonti, S.; Chiarelli-Alvisi, G.: Kynurenine-3-hydroxylase of Schistocera gregaria. Insect Biochem., 4, 9–16 (1974)

    Google Scholar 

  10. Stratakis, E.: Subcellular localization and properties of kynurenine 3-hydroxylase from eggs of Ephestia kuhniella Z. J. Comp. Physiol., 141, 451–456 (1981)

    CAS  Google Scholar 

  11. Shin, M.; Sano, K.; Umezawa, C.: Inhibition of l-kynurenine 3-hydroxylase from Saccharomyces carlsbergensis by α-keto acid derivatives of branched chain amino acids. J. Nutr. Sci. Vitaminol., 28, 191–201 (1982)

    PubMed  CAS  Google Scholar 

  12. Giordani A.; Pevarello P.; Cini, M.; Bormetti, R.; Greco, F.; Toma, S.; Speciale, C.; Varasi, M.: 4-phenyl-4-oxo-butanoic acid derivatives inhibitors of kynurenine 3-hydroxylase. Bioorg. Med. Chem. Lett., 8, 2907–2012 (1998)

    Article  PubMed  CAS  Google Scholar 

  13. Speciale, C.; Cini, M.; Wu, H.Q.; Salvati, P.; Schwarcz, R.; Molinari, A.; Calabresi, M.; Varasi, M.: Kynurenic acid-enhancing and anti-ischemic effects of the potent kynurenine 3-hydroxylase inhibitor FCE28833 in rodents. Adv. Exp. Med. Biol., 398, 221–227 (1996)

    PubMed  CAS  Google Scholar 

  14. Rover, S.; Cesura, A.M.; Huguenin, P.; Kettler, R.; Szente, A.: Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase. J. Med. Chem., 40, 4378–4385 (1997)

    Article  PubMed  CAS  Google Scholar 

  15. Uemura, T.; Hirai, K.: Purification of l-kynurenine 3-monooxygenase from mitochondrial outer membrane of pig liver. Adv. Exp. Med. Biol., 467, 619–623 (1999)

    PubMed  CAS  Google Scholar 

  16. Cozzi, A.; Carpenedo, R.; Moroni, E: Kynurenine hydroxylase inhibitors reduce ischemic brain damage: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(nitrophenyl)thiazol-2yl]-benzenesulfonamide (Ro 61-8048) in models of focal or global brain ischemia. J. Cereb. Blood Flow Metab., 19, 771–777 (1999)

    Article  PubMed  CAS  Google Scholar 

  17. Heidempergher, E; Pevarello, E; Pillan, A.; Pinciroli, V.; Torre, A.D.; Speciale, C.; Marconi, M.; Cini, M.; Toma, S.; Greco, E; Varasi, M.: Pyrrolo[3,2-c]quinoline derivates: a new class of kynurenine-3-hydroxylase inhibitors. Farmaco, 54, 152–160 (1999)

    Article  PubMed  CAS  Google Scholar 

  18. Breton, J.; Avanzi, N.; Magagnin, S.; Covini, N.; Magistrelli, G.; Cozzi, L.; Isacchi, A.: Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase. Eur. J. Biochem., 267, 1092–1099 (2000)

    Article  PubMed  CAS  Google Scholar 

  19. Chiarugi, A.; Cozzi, A.; Massacesik L.; Moroni, F.: Kynurenine 3-momooxygenase activity and neurotoxic kynurenine metabolites increase in the spinal cord of rats with experimental allergic encephalomyelitis. Neurosci., 102, 687–695 (2001)

    Article  CAS  Google Scholar 

  20. Drysdale, M.J.; Hind, S.L.; Jansen, M.; Reinhard, J.F. Jr: Synthesis and SAR of 4-aryl-2-hydroxy-4-oxobut-2-enoic acids and esters and 2-amino-4-aryl-4-oxobut-2-enoic acids and esters: Potent inhibitors of kynurenine-3-hydroxylase as potential neuroprotective agents. J. Med. Chem., 43, 123–127 (2000)

    Article  PubMed  CAS  Google Scholar 

  21. Urenjak, J.; Obrenowitch, T.P.: Kynurenine 3-hydroxylase inhibition in rats: Effects on extracellular kynurenic acid concentration and N-methyl-d-aspartate-induced depolarisation in the striatum. J. Neurochem., 75, 2427–2433 (2000)

    Article  PubMed  CAS  Google Scholar 

  22. Alberati-Giani, D.; Cesuura, A.M.; Broger, C.; Warren, W.D.; Rover, S.; Malherbe, P.: Cloning and functional expression of human kynurenine 3-monooxygenase. FEBS Lett., 410, 407–412 (1997)

    Article  PubMed  CAS  Google Scholar 

  23. Pellicciari, R.; Natalini, B.; Costantino, G.; Mahmoud, M.R.; Mattoli, L.; Sadeghpour, B.M.; Moroni, E; Chiarugi, A.; Carpenedo, R.: Modulation of the kynurenine pathway in search for new neruoprotective agents. Synthesis and preliminary evaluation of (m-nitrobenzoys)alanine, a potent inhibitor of kynurenine-3-hydroxylase. J. Med. Chem., 37, 647–655 (1994)

    Article  PubMed  CAS  Google Scholar 

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© 2006 Springer-Verlag Berlin Heidelberg

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(2006). Kynurenine 3-monooxygenase. In: Class 1 Oxidoreductases XI. Springer Handbook of Enzymes, vol 26. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-37708-5_48

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