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Molecular Genetic Applications to the Diagnosis of Lymphoma

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Molecular Diagnostics

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Abstract

One of the earliest descriptions of primary tumors of lymph nodes was by Thomas Hodgkin in 1832. His publication entitled “On Some Morbid Appearances of the Absorbent Glands and Spleen” reported the clinical characteristics and post mortem findings from seven patients with an unusual disease of lymph nodes (1). Some 30 yr later, the term “Hodgkin’s disease” was introduced by Sir Samuel Wilks in honor of the work of Thomas Hodgkin (2).

Today, the malignant lymphomas are regarded as a heterogeneous group of neoplasms, which can be broadly categorized into two groups: Hodgkin’s lymphoma (formerly Hodgkin’s disease) and non-Hodgkin’s lymphoma. These neoplasms most often arise in lymphoid tissues such as lymph nodes and spleen, but could arise virtually anywhere in the body. M a lignant lym-phoma comprises approx 5% of new cancer cases in the United States annually, with approx 53,400 new cases of non-Hodgkin’s lymphoma and 7,600 new cases of Hodgkin’s lym-phoma expected in 2003 (3).

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Hartford Hospital, Hartford, CT, USA

    William N. Rezuke Jr

  2. Department of Pathology, Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA

    Gregory J. Tsongalis

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  2. Gregory J. Tsongalis
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Editors and Affiliations

  1. Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA

    William B. Coleman

  2. Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA

    Gregory J. Tsongalis

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© 2006 Humana Press, a part of Springer Science+Business Media, LLC

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Rezuke, W.N., Tsongalis, G.J. (2006). Molecular Genetic Applications to the Diagnosis of Lymphoma. In: Coleman, W.B., Tsongalis, G.J. (eds) Molecular Diagnostics. Humana Press. https://doi.org/10.1385/1-59259-928-1:393

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  • DOI: https://doi.org/10.1385/1-59259-928-1:393

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-356-5

  • Online ISBN: 978-1-59259-928-8

  • eBook Packages: MedicineMedicine (R0)

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