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Editing and modification in trypanosomatids: the reshaping of non-coding RNAs

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Fine-Tuning of RNA Functions by Modification and Editing

Part of the book series: Topics in Current Genetics ((TCG,volume 12))

Abstract

Trypanosomatids include a number of protozoan parasites that infect over 27 million people worldwide. Besides their medical importance, these organisms have also provided a wealth of novel biological discoveries including: RNA editing, mRNA trans-splicing, eukaryotic poly-cistronic transcription, and a mechanism for large-scale mitochondrial tRNA import. For many years, the study of RNA post-transcriptional modification in trypanosomatids has lagged behind when compared to bacterial, yeast, and animal systems. However, the discovery of editing in tRNA and 7SL RNAs has produced renewed interest in the processing of non-coding RNAs in these organisms. This chapter will compile what is currently known about RNA editing and modification in trypanosomatids, emphasizing the role these processes play in the structural reshaping of non-coding RNAs. Due to a number of substantive recent reviews, mRNA editing will not be the subject of this chapter. In addition, snoRNA-mediated modification of ribosomal RNAs will be covered in chapter 8 of this book.

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Author information

Authors and Affiliations

  1. Department of Microbiology, The Ohio State University, 484 West 12th Avenue, Columbus, Ohio 43210, USA

    Mary Anne T. Rubio

  2. Department of Microbiology and the Ohio State Biochemistry Program, The Ohio State University, 484 West 12th Avenue, Columbus, Ohio 43210, USA.

    Juan D. Alfonzo

Authors
  1. Mary Anne T. Rubio
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  2. Juan D. Alfonzo
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Henri Grosjean

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Rubio, M.A.T., Alfonzo, J.D. Editing and modification in trypanosomatids: the reshaping of non-coding RNAs. In: Grosjean, H. (eds) Fine-Tuning of RNA Functions by Modification and Editing. Topics in Current Genetics, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/b106363

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