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Nucleotide methylations in rRNA that confer resistance to ribosome-targeting antibiotics

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Fine-Tuning of RNA Functions by Modification and Editing

Part of the book series: Topics in Current Genetics ((TCG,volume 12))

Abstract

Methylation of rRNA nucleotides is an effective means of conferring resistance to antibiotics that target the bacterial ribosome. This type of resistance seems to have evolved as self-defence mechanisms in bacteria such as Streptomyces species that synthesize ribosome-targeting drugs. The self-defence mechanisms were subsequently recruited by pathogenic bacteria including streptococcal and staphylococcal species, where resistance to macrolides and related drugs is now a prevalent clinical problem. In this article, we review the methylation events in bacterial rRNA that confer resistance, and discuss how the molecular mechanisms of resistance can be explained from the recent crystal structures of antibiotics bound to the ribosome.

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  1. Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230 Odense M, Denmark emailsrd@bmb.sdu.dk,  

    Stephen Douthwaite

  2. Laboratoire de RMN, ICSN-CNRS, 1 ave de la terrasse, 91190 Gif-sur-Yvette, France

    Dominique Fourmy & Satoko Yoshizawa

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  1. Stephen Douthwaite
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Henri Grosjean

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Douthwaite, S., Fourmy, D., Yoshizawa, S. Nucleotide methylations in rRNA that confer resistance to ribosome-targeting antibiotics. In: Grosjean, H. (eds) Fine-Tuning of RNA Functions by Modification and Editing. Topics in Current Genetics, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/b105586

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